ENSDARG00000054879


Danio rerio

Features
Gene ID: ENSDARG00000054879
  
Biological name :six3b
  
Synonyms : six3b / SIX homeobox 3b
  
Possible biological names infered from orthology : Homeobox protein SIX3 / O95343 / Q62233 / SIX3 / SIX homeobox 3
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 25600685
Gene end: 25603341
  
Corresponding Affymetrix probe sets: Dr.615.1.S1_at (Zebrafish Array)   NM_131363_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000071625
NCBI entrez gene - 30636     See in Manteia.
RefSeq - NM_131363
RefSeq Peptide - NP_571438
swissprot - O73709
ZFIN ID - ZDB-GENE-990415-128
Ensembl - ENSDARG00000054879
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIX3ENSGALG00000032259Gallus gallus
 SIX3ENSG00000138083Homo sapiens
 Six3ENSMUSG00000038805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
six3a / SIX homeobox 3a / SIX3* / Q62233* / O95343* / SIX homeobox 3* / Homeobox protein SIX3 *ENSDARG0000005800889
six6a / SIX homeobox 6a / SIX6* / Q9QZ28* / O95475* / SIX homeobox 6* / sine oculis-related homeobox 6*ENSDARG0000002518765
six6b / SIX homeobox 6b / SIX6* / Q9QZ28* / O95475* / SIX homeobox 6* / sine oculis-related homeobox 6*ENSDARG0000003131664
six7 / SIX homeobox 7ENSDARG0000007010757
six1b / Q6NZ04 / SIX homeobox 1b / SIX1* / Q62231* / Q15475* / SIX homeobox 1* / Homeobox protein SIX1 *ENSDARG0000002647345
six2a / SIX homeobox 2a / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005800445
six1a / Q6DHF9 / SIX homeobox 1a / SIX1* / Q62231* / Q15475* / SIX homeobox 1* / Homeobox protein SIX1 *ENSDARG0000003930445
six2b / SIX homeobox 2b / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005487844
six4a / SIX homeobox 4a / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000000469542
six4b / SIX homeobox 4b / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000003198340
six9 / SIX homeobox 9ENSDARG0000006840738
six5 / SIX homeobox 5 / P70178* / Q8N196* / Homeobox protein SIX5 *ENSDARG0000006840635


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR031701  Homeobox protein SIX1, N-terminal SD domain
 IPR032949  Homeobox protein SIX3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0021554 optic nerve development IGI
 biological_processGO:0021631 optic nerve morphogenesis IGI
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IGI
 biological_processGO:0070654 sensory epithelium regeneration IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus anterior region absent , abnormal
hypothalamus posterior region decreased distribution , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure fused with anterior commissure , abnormal
postoptic commissure adjacent to anterior commissure , abnormal
Show

 ZFA:0000079 telencephalon telencephalon ventral region decreased amount , abnormal
telencephalon spatial pattern , abnormal
Show

 ZFA:0000101 diencephalon diencephalon spatial pattern , abnormal
diencephalon antero-medial region decreased amount , abnormal
Show

 ZFA:0000107 eye eye absent , abnormal
eye decreased amount , abnormal
eye decreased size , abnormal
Show

 ZFA:0000137 optic stalk optic stalk absent , abnormal
optic stalk increased width , abnormal
optic stalk optic nerve development process quality , abnormal
optic stalk decreased distribution , abnormal
optic stalk increased amount , abnormal
optic stalk optic nerve development arrested , abnormal
optic stalk optic nerve morphogenesis arrested , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium medial region incomplete structure , abnormal
Show

 ZFA:0000152 retina retina has fewer parts of type retinal cone cell , abnormal
retina sensory epithelium regeneration decreased occurrence , abnormal
retina stem cell proliferation decreased occurrence , abnormal
retina wholly dorsalized , abnormal
retina dorsal region increased distribution , abnormal
retina ventral region decreased amount , abnormal
retina protruding into brain , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II hypoplastic , abnormal
cranial nerve II defasciculated , abnormal
Show

 ZFA:0000470 preoptic area preoptic area absent , abnormal
preoptic area decreased size , abnormal
preoptic area decreased amount , abnormal
Show

 ZFA:0000556 optic chiasm optic chiasm absent , abnormal
Show

 ZFA:0001331 outer limiting membrane outer limiting membrane irregular spatial pattern , abnormal
Show

 ZFA:0005491 optic furrow optic furrow decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
retinal ganglion cell neuron differentiation delayed , abnormal
retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon defasciculated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr