ENSG00000170577


Homo sapiens

Features
Gene ID: ENSG00000170577
  
Biological name :SIX2
  
Synonyms : Q9NPC8 / SIX2 / SIX homeobox 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p21
Gene start: 45005161
Gene end: 45009430
  
Corresponding Affymetrix probe sets: 206510_at (Human Genome U133 Plus 2.0 Array)   206511_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304502
NCBI entrez gene - 10736     See in Manteia.
OMIM - 604994
RefSeq - NM_016932
RefSeq - XM_005264100
RefSeq Peptide - NP_058628
swissprot - Q9NPC8
Ensembl - ENSG00000170577
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six2aENSDARG00000058004Danio rerio
 six2bENSDARG00000054878Danio rerio
 SIX2ENSGALG00000023303Gallus gallus
 Six2ENSMUSG00000024134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIX1 / Q15475 / SIX homeobox 1ENSG0000012677875
SIX4 / Q9UIU6 / SIX homeobox 4ENSG0000010062551
SIX5 / Q8N196 / SIX homeobox 5ENSG0000017704549
SIX3 / O95343 / SIX homeobox 3ENSG0000013808348
SIX6 / O95475 / SIX homeobox 6ENSG0000018430248


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007501 mesodermal cell fate specification IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0032330 regulation of chondrocyte differentiation IEA
 biological_processGO:0042474 middle ear morphogenesis IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0072006 nephron development IEA
 biological_processGO:0072028 nephron morphogenesis IEA
 biological_processGO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis IEA
 biological_processGO:0072137 condensed mesenchymal cell proliferation IEA
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IEA
 biological_processGO:0090189 regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0097168 mesenchymal stem cell proliferation IEA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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