ENSG00000100625


Homo sapiens

Features
Gene ID: ENSG00000100625
  
Biological name :SIX4
  
Synonyms : Q9UIU6 / SIX4 / SIX homeobox 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q23.1
Gene start: 60709528
Gene end: 60724348
  
Corresponding Affymetrix probe sets: 229796_at (Human Genome U133 Plus 2.0 Array)   231797_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216513
Ensembl peptide - ENSP00000450761
NCBI entrez gene - 51804     See in Manteia.
OMIM - 606342
RefSeq - XM_005267759
RefSeq - NM_017420
RefSeq Peptide - NP_059116
swissprot - Q9UIU6
swissprot - G3V2N2
Ensembl - ENSG00000100625
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six4aENSDARG00000004695Danio rerio
 six4bENSDARG00000031983Danio rerio
 SIX4ENSGALG00000017389Gallus gallus
 Six4ENSMUSG00000034460Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIX5 / Q8N196 / SIX homeobox 5ENSG0000017704530
SIX2 / Q9NPC8 / SIX homeobox 2ENSG0000017057719
SIX1 / Q15475 / SIX homeobox 1ENSG0000012677818
SIX3 / O95343 / SIX homeobox 3ENSG0000013808315
SIX6 / O95475 / SIX homeobox 6ENSG0000018430215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008582 regulation of synaptic growth at neuromuscular junction IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0030238 male sex determination IEA
 biological_processGO:0030910 olfactory placode formation IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046661 male sex differentiation IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048699 generation of neurons IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048856 anatomical structure development IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0061055 myotome development IEA
 biological_processGO:0061197 fungiform papilla morphogenesis IEA
 biological_processGO:0061551 trigeminal ganglion development IEA
 biological_processGO:0072075 metanephric mesenchyme development IEA
 biological_processGO:0072095 regulation of branch elongation involved in ureteric bud branching IEA
 biological_processGO:0072107 positive regulation of ureteric bud formation IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0098528 skeletal muscle fiber differentiation IEA
 biological_processGO:1902725 negative regulation of satellite cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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