21812


Mus musculus (NCBI)

Features
Gene ID: 21812
  
Biological name :
  
Synonyms : ALK5|AU017191|Alk-5|ESK2|TGFR-1|TbetaR-I|TbetaRI / Tgfbr1 / transforming growth factor, beta receptor I
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1420893_a_at (Mouse Genome 430 2.0 Array)   1420894_at (Mouse Genome 430 2.0 Array)   1420895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 1039767195
RefSeq - 6678323
RefSeq - 918410268
RefSeq - 918410270
RefSeq - NC_000070.6
RefSeq - NP_001299797.1
RefSeq - NP_001299798.1
RefSeq - NP_033396.1
RefSeq - XP_017175592.1
RefSeq - NM_001312868.1
RefSeq - NM_001312869.1
RefSeq - NM_009370.3
RefSeq - XM_017320103.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000007613 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISO
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0001824 blastocyst development IDA
 biological_processGO:0001837 epithelial to mesenchymal transition ISO
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IGI
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007389 pattern specification process IBA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IGI
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031396 regulation of protein ubiquitination ISO
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0032924 activin receptor signaling pathway IBA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045602 negative regulation of endothelial cell differentiation ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048705 skeletal system morphogenesis IGI
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0048870 cell motility ISO
 biological_processGO:0051272 positive regulation of cellular component movement ISO
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IGI
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0060017 parathyroid gland development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060037 pharyngeal system development IMP
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISO
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis IMP
 biological_processGO:0060982 coronary artery morphogenesis IMP
 biological_processGO:0070723 response to cholesterol ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISO
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:1905075 positive regulation of occluding junction disassembly IGI
 biological_processGO:1905223 epicardium morphogenesis IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway ISO
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0048179 activin receptor complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity ISO
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I ISO
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0044877 protein-containing complex binding ISO
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0048185 activin binding IBA
 molecular_functionGO:0050431 transforming growth factor beta binding ISO
 molecular_functionGO:0070411 I-SMAD binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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