22059


Mus musculus (NCBI)

Features
Gene ID: 22059
  
Biological name :
  
Synonyms : Tp53|bbl|bfy|bhy|p44|p53 / transformation related protein 53 / Trp53
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1426538_a_at (Mouse Genome 430 2.0 Array)   1427739_a_at (Mouse Genome 430 2.0 Array)   1438808_at (Mouse Genome 430 2.0 Array)   1457623_x_at (Mouse Genome 430 2.0 Array)   1459780_at (Mouse Genome 430 2.0 Array)   1459781_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 148747262
RefSeq - 187960040
RefSeq - 568973603
RefSeq - NC_000077.6
RefSeq - NP_001120705.1
RefSeq - NP_035770.2
RefSeq - XP_006533220.1
RefSeq - NM_001127233.1
RefSeq - NM_011640.3
RefSeq - XM_006533157.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000059552 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000733 DNA strand renaturation ISO
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001836 release of cytochrome c from mitochondria IGI
 biological_processGO:0002309 T cell proliferation involved in immune response IGI
 biological_processGO:0002326 B cell lineage commitment IMP
 biological_processGO:0002360 T cell lineage commitment IMP
 biological_processGO:0002687 positive regulation of leukocyte migration ISO
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0006289 nucleotide-excision repair ISO
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0006915 apoptotic process IGI
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0006983 ER overload response ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0007275 multicellular organism development ISO
 biological_processGO:0007369 gastrulation IGI
 biological_processGO:0007406 negative regulation of neuroblast proliferation IGI
 biological_processGO:0007417 central nervous system development IGI
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007569 cell aging ISO
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0009299 mRNA transcription ISO
 biological_processGO:0009303 rRNA transcription IGI
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0009651 response to salt stress IGI
 biological_processGO:0009792 embryo development ending in birth or egg hatching IGI
 biological_processGO:0010165 response to X-ray IMP
 biological_processGO:0010332 response to gamma radiation ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016032 viral process ISO
 biological_processGO:0021549 cerebellum development IDA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0031065 positive regulation of histone deacetylation IDA
 biological_processGO:0031497 chromatin assembly ISO
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint ISO
 biological_processGO:0032461 positive regulation of protein oligomerization ISO
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0034103 regulation of tissue remodeling IMP
 biological_processGO:0034613 cellular protein localization ISO
 biological_processGO:0034614 cellular response to reactive oxygen species ISO
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0035794 positive regulation of mitochondrial membrane permeability IGI
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IDA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043504 mitochondrial DNA repair IMP
 biological_processGO:0043523 regulation of neuron apoptotic process IGI
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0045787 positive regulation of cell cycle ISO
 biological_processGO:0045861 negative regulation of proteolysis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly ISO
 biological_processGO:0045930 negative regulation of mitotic cell cycle IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048512 circadian behavior IMP
 biological_processGO:0048568 embryonic organ development IGI
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050821 protein stabilization IGI
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051276 chromosome organization IGI
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051453 regulation of intracellular pH ISO
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051974 negative regulation of telomerase activity ISO
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060411 cardiac septum morphogenesis IGI
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0065003 protein-containing complex assembly ISO
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0070243 regulation of thymocyte apoptotic process IGI
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IMP
 biological_processGO:0070266 necroptotic process IGI
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:0071494 cellular response to UV-C IGI
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:0072331 signal transduction by p53 class mediator ISO
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:0072363 regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:0072717 cellular response to actinomycin D ISO
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISO
 biological_processGO:0090343 positive regulation of cell aging IMP
 biological_processGO:0090399 replicative senescence ISO
 biological_processGO:0090403 oxidative stress-induced premature senescence ISO
 biological_processGO:0097252 oligodendrocyte apoptotic process ISO
 biological_processGO:1900119 positive regulation of execution phase of apoptosis ISO
 biological_processGO:1901525 negative regulation of mitophagy IMP
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1903205 regulation of hydrogen peroxide-induced cell death ISO
 biological_processGO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate IMP
 biological_processGO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 biological_processGO:2000269 regulation of fibroblast apoptotic process IGI
 biological_processGO:2000279 negative regulation of DNA biosynthetic process ISO
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2000772 regulation of cellular senescence IGI
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0005669 transcription factor TFIID complex ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
 molecular_functionGO:0000990 transcription factor activity, core RNA polymerase binding ISO
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001074 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IGI
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0001094 TFIID-class transcription factor binding ISO
 molecular_functionGO:0001221 transcription cofactor binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO
 molecular_functionGO:0005507 copper ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0035033 histone deacetylase regulator activity IDA
 molecular_functionGO:0035035 histone acetyltransferase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0043621 protein self-association ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0051087 chaperone binding ISO
 molecular_functionGO:0051721 protein phosphatase 2A binding ISO
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding ISO
 molecular_functionGO:0097718 disordered domain specific binding ISO
 molecular_functionGO:1990841 promoter-specific chromatin binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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