23327


Homo sapiens (NCBI)
regulationproteinionactivitytransmembranesodiumtransportpotassiumchannelmembranecatabolicprocesstransporterubiquitin-dependenthomeostasisubiquitinationpotentialendocytosisdendritecellbindingregulatorinhibitortranscriptionrnapolymeraseiipolyubiquitinationdepolarizationmonoubiquitination

Features
Gene ID: 23327
  
Biological name :
  
Synonyms : NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2 / NEDD4L / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 212445_s_at (Human Genome U133 Plus 2.0 Array)   212448_at (Human Genome U133 Plus 2.0 Array)   226974_at (Human Genome U133 Plus 2.0 Array)   241396_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 578832415
RefSeq - 1034603773
RefSeq - 1034603780
RefSeq - 1034603783
RefSeq - 1034603785
RefSeq - 1034603787
RefSeq - 1370473315
RefSeq - 1370473317
RefSeq - 1370473321
RefSeq - 1370473325
RefSeq - 1370473327
RefSeq - 1370473330
RefSeq - 1370473333
RefSeq - 1370473335
RefSeq - 1370473337
RefSeq - 21361472
RefSeq - 222352082
RefSeq - 222352084
RefSeq - 222352086
RefSeq - 222352088
RefSeq - 222352090
RefSeq - 222352092
RefSeq - 222352094
RefSeq - 222352183
RefSeq - 345478677
RefSeq - 578832411
RefSeq - 1034603771
RefSeq - 578832419
RefSeq - 767998446
RefSeq - 767998449
RefSeq - 767998451
RefSeq - 767998453
RefSeq - 767998456
RefSeq - 767998458
RefSeq - 767998462
RefSeq - NC_000018.10
RefSeq - NG_029954.1
RefSeq - NP_001138436.1
RefSeq - NP_001138437.1
RefSeq - NP_001138438.1
RefSeq - NP_001138439.1
RefSeq - NP_001138440.1
RefSeq - NP_001138441.1
RefSeq - NP_001138442.1
RefSeq - NP_001138443.1
RefSeq - NP_001230889.1
RefSeq - NP_056092.2
RefSeq - XP_005266715.2
RefSeq - XP_005266717.2
RefSeq - XP_005266720.2
RefSeq - XP_006722484.2
RefSeq - XP_006722487.2
RefSeq - XP_006722488.2
RefSeq - XP_006722489.1
RefSeq - XP_006722491.1
RefSeq - XP_006722493.1
RefSeq - XP_011524189.1
RefSeq - XP_016881165.1
RefSeq - XP_016881166.1
RefSeq - XP_016881167.1
RefSeq - XP_016881168.1
RefSeq - XP_016881169.1
RefSeq - XP_016881170.1
RefSeq - XP_024306897.1
RefSeq - XP_024306898.1
RefSeq - XP_024306899.1
RefSeq - XP_024306900.1
RefSeq - XP_024306901.1
RefSeq - XP_024306902.1
RefSeq - XP_024306903.1
RefSeq - XP_024306904.1
RefSeq - XP_024306905.1
RefSeq - NM_001144964.1
RefSeq - NM_001144965.1
RefSeq - NM_001144966.2
RefSeq - NM_001144967.2
RefSeq - NM_001144968.1
RefSeq - NM_001144969.1
RefSeq - NM_001144970.2
RefSeq - NM_001144971.1
RefSeq - NM_001243960.1
RefSeq - NM_015277.5
RefSeq - XM_017025681.2
RefSeq - XM_024451129.1
RefSeq - XM_024451130.1
RefSeq - XM_024451131.1
RefSeq - XM_024451132.1
RefSeq - XM_024451133.1
RefSeq - XM_024451134.1
RefSeq - XM_024451135.1
RefSeq - XM_024451136.1
RefSeq - XM_024451137.1
RefSeq - XM_005266658.4
RefSeq - XM_005266660.4
RefSeq - XM_005266663.4
RefSeq - XM_006722421.4
RefSeq - XM_006722424.3
RefSeq - XM_006722425.3
RefSeq - XM_006722426.4
RefSeq - XM_006722428.4
RefSeq - XM_006722430.4
RefSeq - XM_011525887.3
RefSeq - XM_017025676.1
RefSeq - XM_017025677.1
RefSeq - XM_017025678.2
RefSeq - XM_017025679.2
RefSeq - XM_017025680.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000049759 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitycatabolic processestablishment of localizationsystem processresponse to chemicalinterspecies interaction between organismscellular component organizationanatomical structure developmentcellular developmental processmovement of cell or subcellular componentactin filament-based processregulation of molecular functioncell growthdevelopmental growthmacromolecule localizationcellular localizationnitrognitrogen compound metabolic processbiosynbiosynthetic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processregularegulation of biological qualitycatabocatabolic processestablestablishment of localizationsystemsystem processresponresponse to chemicalintersinterspecies interaction between organismscellulcellular component organizationanatomanatomical structure developmentcellulcellular developmental processmovememovement of cell or subcellular componentactin actin filament-based processregularegulation of molecular functioncell gcell growthdevelodevelopmental growthmacrommacromolecule localizationcellulcellular localization
catalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingchannel regulator activitycatalytic activity, acting on a procatalytic activity, acting on a proteintransferase activitytransferase activityprotein bindingprotein bindingchannel regulator activitychannel regulator activity
cellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0003254 regulation of membrane depolarization IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006814 sodium ion transport NAS
 biological_processGO:0006883 cellular sodium ion homeostasis NAS
 biological_processGO:0007588 excretion NAS
 biological_processGO:0010038 response to metal ion IDA
 biological_processGO:0016567 protein ubiquitination NAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0030104 water homeostasis NAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IDA
 biological_processGO:0042176 regulation of protein catabolic process NAS
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045807 positive regulation of endocytosis NAS
 biological_processGO:0048814 regulation of dendrite morphogenesis IBA
 biological_processGO:0060306 regulation of membrane repolarization IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0086005 ventricular cardiac muscle cell action potential ISS
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IDA
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IDA
 biological_processGO:1901380 negative regulation of potassium ion transmembrane transport IDA
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport IDA
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IDA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IDA
 biological_processGO:2001288 positive regulation of caveolin-mediated endocytosis ISS
 cellular_componentGO:0005622 intracellular IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity IDA
 molecular_functionGO:0017080 sodium channel regulator activity IDA
 molecular_functionGO:0019870 potassium channel inhibitor activity IDA
 molecular_functionGO:0019871 sodium channel inhibitor activity IDA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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