255738


Homo sapiens (NCBI)

Features
Gene ID: 255738
  
Biological name :
  
Synonyms : FH3|HCHOLA3|LDLCQ1|NARC-1|NARC1|PC9 / PCSK9 / proprotein convertase subtilisin/kexin type 9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 227759_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 31317307
RefSeq - NC_000001.11
RefSeq - NG_009061.1
RefSeq - NP_777596.2
RefSeq - NM_174936.3
RefSeq - NR_110451.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000169174 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001889 liver development ISS
 biological_processGO:0001920 negative regulation of receptor recycling IDA
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007041 lysosomal transport IDA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0010469 regulation of signaling receptor activity IDA
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IDA
 biological_processGO:0016540 protein autoprocessing IDA
 biological_processGO:0022008 neurogenesis ISS
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process IDA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043523 regulation of neuron apoptotic process ISS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:1905596 negative regulation of low-density lipoprotein particle receptor binding IDA
 biological_processGO:1905598 negative regulation of low-density lipoprotein receptor activity IDA
 biological_processGO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
 biological_processGO:2000272 negative regulation of signaling receptor activity IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane IC
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:1990666 PCSK9-LDLR complex IDA
 cellular_componentGO:1990667 PCSK9-AnxA2 complex IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019871 sodium channel inhibitor activity IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding ISS
 molecular_functionGO:0030547 receptor inhibitor activity IDA
 molecular_functionGO:0034185 apolipoprotein binding ISS
 molecular_functionGO:0034189 very-low-density lipoprotein particle binding ISS
 molecular_functionGO:0034190 apolipoprotein receptor binding IDA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IPI
 molecular_functionGO:0070326 very-low-density lipoprotein particle receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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