3077


Homo sapiens (NCBI)

Features
Gene ID: 3077
  
Biological name :
  
Synonyms : HFE / HFE1|HH|HLA-H|MVCD7|TFQTL2 / homeostatic iron regulator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1553402_a_at (Human Genome U133 Plus 2.0 Array)   206086_x_at (Human Genome U133 Plus 2.0 Array)   206087_x_at (Human Genome U133 Plus 2.0 Array)   210864_x_at (Human Genome U133 Plus 2.0 Array)   211326_x_at (Human Genome U133 Plus 2.0 Array)   211327_x_at (Human Genome U133 Plus 2.0 Array)   211328_x_at (Human Genome U133 Plus 2.0 Array)   211329_x_at (Human Genome U133 Plus 2.0 Array)   211330_s_at (Human Genome U133 Plus 2.0 Array)   211331_x_at (Human Genome U133 Plus 2.0 Array)   211332_x_at (Human Genome U133 Plus 2.0 Array)   211863_x_at (Human Genome U133 Plus 2.0 Array)   211866_x_at (Human Genome U133 Plus 2.0 Array)   214647_s_at (Human Genome U133 Plus 2.0 Array)   235754_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NG_008720.2
RefSeq - NP_000401.1
RefSeq - NP_001287678.1
RefSeq - NP_620572.1
RefSeq - NP_620573.1
RefSeq - NP_620575.1
RefSeq - NP_620576.1
RefSeq - NP_620577.1
RefSeq - NP_620578.1
RefSeq - NP_620579.1
RefSeq - NP_620580.1
RefSeq - 21040343
RefSeq - XP_011512845.1
RefSeq - 21040341
RefSeq - 21040347
RefSeq - 21040349
RefSeq - 21040351
RefSeq - 21040353
RefSeq - 21040355
RefSeq - 21040357
RefSeq - 4504377
RefSeq - 663429517
RefSeq - 767939870
RefSeq - NC_000006.12
RefSeq - XR_241893.4
RefSeq - NM_000410.3
RefSeq - NM_001300749.1
RefSeq - NM_139002.2
RefSeq - NM_139003.2
RefSeq - NM_139004.2
RefSeq - NM_139005.2
RefSeq - NM_139006.2
RefSeq - NM_139007.2
RefSeq - NM_139008.2
RefSeq - NM_139009.2
RefSeq - NM_139010.2
RefSeq - NM_139011.2
RefSeq - XM_011514543.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000010704 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001913 T cell mediated cytotoxicity IBA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IKR
 biological_processGO:0002626 negative regulation of T cell antigen processing and presentation IEA
 biological_processGO:0002725 negative regulation of T cell cytokine production IGI
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0010039 response to iron ion IMP
 biological_processGO:0010106 cellular response to iron ion starvation IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0019882 antigen processing and presentation IC
 biological_processGO:0030101 natural killer cell activation IBA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0032092 positive regulation of protein binding IGI
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IC
 biological_processGO:0033572 transferrin transport TAS
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IBA
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IBA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IGI
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0071281 cellular response to iron ion IGI
 biological_processGO:0090277 positive regulation of peptide hormone secretion IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0098711 iron ion import across plasma membrane IDA
 biological_processGO:1900121 negative regulation of receptor binding IDA
 biological_processGO:1900122 positive regulation of receptor binding IGI
 biological_processGO:1900390 regulation of iron ion import IGI
 biological_processGO:1904283 negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I IGI
 biological_processGO:1904434 positive regulation of ferrous iron binding IGI
 biological_processGO:1904437 positive regulation of transferrin receptor binding IGI
 biological_processGO:1990641 response to iron ion starvation IEA
 biological_processGO:2000008 regulation of protein localization to cell surface IMP
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IDA
 biological_processGO:2000272 negative regulation of signaling receptor activity IDA
 biological_processGO:2000273 positive regulation of signaling receptor activity IGI
 biological_processGO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation IGI
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042612 MHC class I protein complex IKR
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:1990357 terminal web IEA
 cellular_componentGO:1990712 HFE-transferrin receptor complex IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030881 beta-2-microglobulin binding IPI
 molecular_functionGO:0039706 co-receptor binding IPI
 molecular_functionGO:0042605 peptide antigen binding IKR
 molecular_functionGO:0046703 natural killer cell lectin-like receptor binding IBA
 molecular_functionGO:1990459 transferrin receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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