348


Homo sapiens (NCBI)

Features
Gene ID: 348
  
Biological name :
  
Synonyms : AD2|APO-E|ApoE4|LDLCQ5|LPG / APOE / apolipoprotein E
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 203381_s_at (Human Genome U133 Plus 2.0 Array)   203382_s_at (Human Genome U133 Plus 2.0 Array)   212884_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4557325
RefSeq - 705044002
RefSeq - 705044063
RefSeq - 705044104
RefSeq - 705044152
RefSeq - NC_000019.10
RefSeq - NG_007084.2
RefSeq - NP_000032.1
RefSeq - NP_001289617.1
RefSeq - NP_001289618.1
RefSeq - NP_001289619.1
RefSeq - NP_001289620.1
RefSeq - NM_000041.3
RefSeq - NM_001302688.1
RefSeq - NM_001302689.1
RefSeq - NM_001302690.1
RefSeq - NM_001302691.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000130203 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species NAS
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0002021 response to dietary excess IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006707 cholesterol catabolic process IBA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007263 nitric oxide mediated signal transduction IDA
 biological_processGO:0007271 synaptic transmission, cholinergic TAS
 biological_processGO:0007616 long-term memory IGI
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0010544 negative regulation of platelet activation IDA
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010873 positive regulation of cholesterol esterification IDA
 biological_processGO:0010875 positive regulation of cholesterol efflux IGI
 biological_processGO:0010877 lipid transport involved in lipid storage ISS
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0015909 long-chain fatty acid transport IDA
 biological_processGO:0017038 protein import IDA
 biological_processGO:0019068 virion assembly IMP
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0019934 cGMP-mediated signaling IDA
 biological_processGO:0030195 negative regulation of blood coagulation IDA
 biological_processGO:0030516 regulation of axon extension TAS
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IGI
 biological_processGO:0032374 regulation of cholesterol transport IBA
 biological_processGO:0032462 regulation of protein homooligomerization IDA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IDA
 biological_processGO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process IDA
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IDA
 biological_processGO:0034371 chylomicron remodeling TAS
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IGI
 biological_processGO:0034374 low-density lipoprotein particle remodeling IEA
 biological_processGO:0034375 high-density lipoprotein particle remodeling TAS
 biological_processGO:0034378 chylomicron assembly TAS
 biological_processGO:0034380 high-density lipoprotein particle assembly IDA
 biological_processGO:0034382 chylomicron remnant clearance TAS
 biological_processGO:0034384 high-density lipoprotein particle clearance IDA
 biological_processGO:0034447 very-low-density lipoprotein particle clearance IMP
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0042157 lipoprotein metabolic process IBA
 biological_processGO:0042158 lipoprotein biosynthetic process IEA
 biological_processGO:0042159 lipoprotein catabolic process IBA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042632 cholesterol homeostasis IGI
 biological_processGO:0042982 amyloid precursor protein metabolic process IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0043691 reverse cholesterol transport IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044794 positive regulation by host of viral process IMP
 biological_processGO:0045541 negative regulation of cholesterol biosynthetic process IDA
 biological_processGO:0045807 positive regulation of endocytosis IDA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IDA
 biological_processGO:0046907 intracellular transport TAS
 biological_processGO:0048168 regulation of neuronal synaptic plasticity TAS
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0050728 negative regulation of inflammatory response IC
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IDA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IGI
 biological_processGO:0051246 regulation of protein metabolic process IGI
 biological_processGO:0051651 maintenance of location in cell IEA
 biological_processGO:0055089 fatty acid homeostasis IDA
 biological_processGO:0060999 positive regulation of dendritic spine development IDA
 biological_processGO:0061771 response to caloric restriction IGI
 biological_processGO:0070328 triglyceride homeostasis ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090181 regulation of cholesterol metabolic process IGI
 biological_processGO:0090209 negative regulation of triglyceride metabolic process IEA
 biological_processGO:0097113 AMPA glutamate receptor clustering IDA
 biological_processGO:0097114 NMDA glutamate receptor clustering IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1900221 regulation of amyloid-beta clearance IDA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IDA
 biological_processGO:1901215 negative regulation of neuron death IDA
 biological_processGO:1901628 positive regulation of postsynaptic membrane organization IDA
 biological_processGO:1901630 negative regulation of presynaptic membrane organization IDA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IDA
 biological_processGO:1902952 positive regulation of dendritic spine maintenance IDA
 biological_processGO:1902995 positive regulation of phospholipid efflux IDA
 biological_processGO:1903002 positive regulation of lipid transport across blood brain barrier IDA
 biological_processGO:1905855 positive regulation of heparan sulfate binding IDA
 biological_processGO:1905860 positive regulation of heparan sulfate proteoglycan binding IDA
 biological_processGO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus IDA
 biological_processGO:1905906 regulation of amyloid fibril formation IDA
 biological_processGO:1905908 positive regulation of amyloid fibril formation TAS
 biological_processGO:2000822 regulation of behavioral fear response IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030425 dendrite NAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034362 low-density lipoprotein particle IDA
 cellular_componentGO:0034363 intermediate-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IDA
 cellular_componentGO:0034365 discoidal high-density lipoprotein particle TAS
 cellular_componentGO:0042627 chylomicron IDA
 cellular_componentGO:0043025 neuronal cell body NAS
 cellular_componentGO:0062023 collagen-containing extracellular matrix HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 cellular_componentGO:1990777 lipoprotein particle IDA
 molecular_functionGO:0001540 amyloid-beta binding IPI
 molecular_functionGO:0005198 structural molecule activity TAS
 molecular_functionGO:0005319 lipid transporter activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0016209 antioxidant activity IDA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046911 metal chelating activity IDA
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0048156 tau protein binding IPI
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding NAS
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IDA
 molecular_functionGO:0070326 very-low-density lipoprotein particle receptor binding IPI
 molecular_functionGO:0071813 lipoprotein particle binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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