351


Homo sapiens (NCBI)

Features
Gene ID: 351
  
Biological name :
  
Synonyms : AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 / amyloid beta precursor protein / APP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 200602_at (Human Genome U133 Plus 2.0 Array)   211277_x_at (Human Genome U133 Plus 2.0 Array)   214953_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1370481386
RefSeq - 209862833
RefSeq - 209915570
RefSeq - 209915573
RefSeq - 209915575
RefSeq - 324021736
RefSeq - 324021738
RefSeq - 324021740
RefSeq - 41406055
RefSeq - 41406057
RefSeq - 4502167
RefSeq - NC_000021.9
RefSeq - NG_007376.1
RefSeq - NP_000475.1
RefSeq - NP_001129488.1
RefSeq - NP_001129601.1
RefSeq - NP_001129602.1
RefSeq - NP_001129603.1
RefSeq - NP_001191230.1
RefSeq - NP_001191231.1
RefSeq - NP_001191232.1
RefSeq - NP_958816.1
RefSeq - NP_958817.1
RefSeq - XP_024307843.1
RefSeq - NM_000484.3
RefSeq - NM_001136016.3
RefSeq - NM_001136129.2
RefSeq - NM_001136130.2
RefSeq - NM_001136131.2
RefSeq - NM_001204301.1
RefSeq - NM_001204302.1
RefSeq - NM_001204303.1
RefSeq - NM_201413.2
RefSeq - NM_201414.2
RefSeq - XM_024452075.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000142192 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0002265 astrocyte activation involved in immune response IGI
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006378 mRNA polyadenylation ISS
 biological_processGO:0006417 regulation of translation ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006878 cellular copper ion homeostasis ISS
 biological_processGO:0006897 endocytosis ISS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0007611 learning or memory TAS
 biological_processGO:0007612 learning IMP
 biological_processGO:0007617 mating behavior ISS
 biological_processGO:0007626 locomotory behavior ISS
 biological_processGO:0008088 axo-dendritic transport ISS
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008344 adult locomotory behavior ISS
 biological_processGO:0008542 visual learning ISS
 biological_processGO:0009987 cellular process IMP
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0014005 microglia development IGI
 biological_processGO:0016199 axon midline choice point recognition ISS
 biological_processGO:0016322 neuron remodeling ISS
 biological_processGO:0016358 dendrite development ISS
 biological_processGO:0030111 regulation of Wnt signaling pathway IC
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0032092 positive regulation of protein binding IGI
 biological_processGO:0032640 tumor necrosis factor production IGI
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway ISS
 biological_processGO:0040014 regulation of multicellular organism growth ISS
 biological_processGO:0042327 positive regulation of phosphorylation IGI
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0048143 astrocyte activation IGI
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IGI
 biological_processGO:0048669 collateral sprouting in absence of injury ISS
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IGI
 biological_processGO:0050803 regulation of synapse structure or activity ISS
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IGI
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IGI
 biological_processGO:0051124 synaptic growth at neuromuscular junction IEA
 biological_processGO:0051247 positive regulation of protein metabolic process ISS
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0061890 positive regulation of astrocyte activation IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071874 cellular response to norepinephrine stimulus IEA
 biological_processGO:0090647 modulation of age-related behavioral decline TAS
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IGI
 biological_processGO:0150003 regulation of spontaneous synaptic transmission IGI
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IGI
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IGI
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1902004 positive regulation of amyloid-beta formation IGI
 biological_processGO:1903980 positive regulation of microglial cell activation IGI
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 biological_processGO:1905598 negative regulation of low-density lipoprotein receptor activity IGI
 biological_processGO:1905908 positive regulation of amyloid fibril formation IMP
 biological_processGO:1990000 amyloid fibril formation IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990535 neuron projection maintenance IGI
 biological_processGO:2000310 regulation of NMDA receptor activity TAS
 biological_processGO:2000406 positive regulation of T cell migration IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0051233 spindle midzone IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 cellular_componentGO:1990812 growth cone filopodium IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046914 transition metal ion binding IEA
 molecular_functionGO:0051425 PTB domain binding IPI
 molecular_functionGO:0070851 growth factor receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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