3815


Homo sapiens (NCBI)

Features
Gene ID: 3815
  
Biological name :
  
Synonyms : C-Kit|CD117|PBT|SCFR / KIT / KIT proto-oncogene receptor tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 205051_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_016863669.1
RefSeq - 1034639797
RefSeq - 1034639799
RefSeq - 148005039
RefSeq - 4557695
RefSeq - 530376783
RefSeq - 530376785
RefSeq - 530376787
RefSeq - NC_000004.12
RefSeq - NG_007456.1
RefSeq - NP_000213.1
RefSeq - NP_001087241.1
RefSeq - XP_005265797.1
RefSeq - XP_005265798.1
RefSeq - XP_005265799.1
RefSeq - XP_016863667.1
RefSeq - XP_016863668.1
RefSeq - 1034639794
RefSeq - NM_000222.2
RefSeq - NM_001093772.1
RefSeq - XM_017008179.1
RefSeq - XM_017008180.1
RefSeq - XM_005265740.1
RefSeq - XM_005265741.1
RefSeq - XM_005265742.3
RefSeq - XM_017008178.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000157404 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001541 ovarian follicle development ISS
 biological_processGO:0002318 myeloid progenitor cell differentiation IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0002327 immature B cell differentiation ISS
 biological_processGO:0002371 dendritic cell cytokine production ISS
 biological_processGO:0002551 mast cell chemotaxis IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006687 glycosphingolipid metabolic process IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008354 germ cell migration IEA
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0008584 male gonad development IEP
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010863 positive regulation of phospholipase C activity TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019827 stem cell population maintenance TAS
 biological_processGO:0030032 lamellipodium assembly ISS
 biological_processGO:0030097 hemopoiesis TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030217 T cell differentiation ISS
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030318 melanocyte differentiation TAS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0032762 mast cell cytokine production IDA
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035162 embryonic hemopoiesis ISS
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0035701 hematopoietic stem cell migration IEA
 biological_processGO:0035855 megakaryocyte development ISS
 biological_processGO:0038093 Fc receptor signaling pathway IDA
 biological_processGO:0038109 Kit signaling pathway IDA
 biological_processGO:0038162 erythropoietin-mediated signaling pathway ISS
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0043303 mast cell degranulation IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043473 pigmentation ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048565 digestive tract development ISS
 biological_processGO:0048863 stem cell differentiation ISS
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound ISS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060374 mast cell differentiation TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0070662 mast cell proliferation TAS
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:0097324 melanocyte migration ISS
 biological_processGO:0097326 melanocyte adhesion ISS
 biological_processGO:0120072 positive regulation of pyloric antrum smooth muscle contraction IEA
 biological_processGO:1904251 regulation of bile acid metabolic process IEA
 biological_processGO:1904343 positive regulation of colon smooth muscle contraction IEA
 biological_processGO:1904349 positive regulation of small intestine smooth muscle contraction IEA
 biological_processGO:1905065 positive regulation of vascular smooth muscle cell differentiation IDA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043235 receptor complex IBA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005020 stem cell factor receptor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019838 growth factor binding IBA
 molecular_functionGO:0019955 cytokine binding IDA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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