4067


Homo sapiens (NCBI)

Features
Gene ID: 4067
  
Biological name :
  
Synonyms : JTK8|p53Lyn|p56Lyn / LYN / LYN proto-oncogene, Src family tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 202625_at (Human Genome U133 Plus 2.0 Array)   202626_s_at (Human Genome U133 Plus 2.0 Array)   210754_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034660270
RefSeq - 1034660272
RefSeq - 162287326
RefSeq - 4505055
RefSeq - 767951784
RefSeq - NC_000008.11
RefSeq - NG_029593.1
RefSeq - NP_001104567.1
RefSeq - NP_002341.1
RefSeq - XP_011515831.1
RefSeq - XP_016868904.1
RefSeq - XP_016868905.1
RefSeq - NM_001111097.2
RefSeq - NM_002350.3
RefSeq - XM_017013415.2
RefSeq - XM_017013416.1
RefSeq - XM_011517529.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000254087 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis ISS
 biological_processGO:0001817 regulation of cytokine production ISS
 biological_processGO:0001932 regulation of protein phosphorylation TAS
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway ISS
 biological_processGO:0002513 tolerance induction to self antigen TAS
 biological_processGO:0002553 histamine secretion by mast cell IEA
 biological_processGO:0002576 platelet degranulation ISS
 biological_processGO:0002762 negative regulation of myeloid leukocyte differentiation IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway TAS
 biological_processGO:0002774 Fc receptor mediated inhibitory signaling pathway ISS
 biological_processGO:0002902 regulation of B cell apoptotic process IBA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006991 response to sterol depletion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IBA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISS
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033003 regulation of mast cell activation ISS
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway ISS
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway ISS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043304 regulation of mast cell degranulation ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045646 regulation of erythrocyte differentiation ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050777 negative regulation of immune response TAS
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0050855 regulation of B cell receptor signaling pathway ISS
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051272 positive regulation of cellular component movement IDA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0070304 positive regulation of stress-activated protein kinase signaling cascade IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070447 positive regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0070667 negative regulation of mast cell proliferation ISS
 biological_processGO:0070668 positive regulation of mast cell proliferation IMP
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0090025 regulation of monocyte chemotaxis IMP
 biological_processGO:0090330 regulation of platelet aggregation ISS
 biological_processGO:0097028 dendritic cell differentiation ISS
 biological_processGO:1902532 negative regulation of intracellular signal transduction ISS
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity NAS
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0043208 glycosphingolipid binding IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0140031 phosphorylation-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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