4361


Homo sapiens (NCBI)

Features
Gene ID: 4361
  
Biological name :
  
Synonyms : ATLD|HNGS1|MRE11A|MRE11B / MRE11 / MRE11 homolog, double strand break repair nuclease
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 205395_s_at (Human Genome U133 Plus 2.0 Array)   211334_at (Human Genome U133 Plus 2.0 Array)   242456_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034573783
RefSeq - 1057866489
RefSeq - 24234690
RefSeq - 5031923
RefSeq - 530396808
RefSeq - 578822201
RefSeq - 767970186
RefSeq - NC_000011.10
RefSeq - NG_007261.1
RefSeq - NP_001317276.1
RefSeq - NP_005581.2
RefSeq - NP_005582.1
RefSeq - XP_005274065.1
RefSeq - XP_006718905.1
RefSeq - XP_011541139.1
RefSeq - XP_016873261.1
RefSeq - XM_006718842.3
RefSeq - NM_001330347.1
RefSeq - NM_005590.3
RefSeq - NM_005591.3
RefSeq - XM_011542837.2
RefSeq - XM_017017772.1
RefSeq - XR_947828.2
RefSeq - XM_005274008.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000020922 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000019 regulation of mitotic recombination TAS
 biological_processGO:0000723 telomere maintenance IBA
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0000729 DNA double-strand break processing TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006302 double-strand break repair TAS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007004 telomere maintenance via telomerase TAS
 biological_processGO:0007062 sister chromatid cohesion IMP
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007131 reciprocal meiotic recombination TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0031860 telomeric 3" overhang formation IMP
 biological_processGO:0031954 positive regulation of protein autophosphorylation IDA
 biological_processGO:0032206 positive regulation of telomere maintenance IMP
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032508 DNA duplex unwinding IMP
 biological_processGO:0032876 negative regulation of DNA endoreduplication IMP
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0042138 meiotic DNA double-strand break formation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0097552 mitochondrial double-strand break repair via homologous recombination IBA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISS
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0030870 Mre11 complex TAS
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding TAS
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IBA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IMP
 molecular_functionGO:0004518 nuclease activity TAS
 molecular_functionGO:0004519 endonuclease activity IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IDA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043047 single-stranded telomeric DNA binding IBA
 molecular_functionGO:0045296 cadherin binding HDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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