468


Homo sapiens (NCBI)

Features
Gene ID: 468
  
Biological name :
  
Synonyms : activating transcription factor 4 / ATF4 / CREB-2|CREB2|TAXREB67|TXREB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 200779_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034629009
RefSeq - 33469974
RefSeq - 33469976
RefSeq - NC_000022.11
RefSeq - NP_001666.2
RefSeq - NP_877962.1
RefSeq - XP_016884296.1
RefSeq - NM_001675.4
RefSeq - NM_182810.2
RefSeq - XM_017028807.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000128272 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0032057 negative regulation of translational initiation in response to stress ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034198 cellular response to amino acid starvation ISS
 biological_processGO:0034644 cellular response to UV ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IC
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IGI
 biological_processGO:1903351 cellular response to dopamine IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 biological_processGO:1990737 response to manganese-induced endoplasmic reticulum stress IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034399 nuclear periphery IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:1990037 Lewy body core IDA
 cellular_componentGO:1990589 ATF4-CREB1 transcription factor complex IDA
 cellular_componentGO:1990590 ATF1-ATF4 transcription factor complex IDA
 cellular_componentGO:1990617 CHOP-ATF4 complex NAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IC
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043522 leucine zipper domain binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding TAS
 molecular_functionGO:0046982 protein heterodimerization activity NAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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