ENSG00000128272


Homo sapiens

Features
Gene ID: ENSG00000128272
  
Biological name :ATF4
  
Synonyms : activating transcription factor 4 / ATF4 / P18848
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 39519695
Gene end: 39522685
  
Corresponding Affymetrix probe sets: 200779_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336790
Ensembl peptide - ENSP00000379912
Ensembl peptide - ENSP00000384587
NCBI entrez gene - 468     See in Manteia.
OMIM - 604064
RefSeq - XM_017028807
RefSeq - NM_001675
RefSeq - NM_182810
RefSeq Peptide - NP_877962
RefSeq Peptide - NP_001666
swissprot - P18848
Ensembl - ENSG00000128272
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf4aENSDARG00000111939Danio rerio
 atf4bENSDARG00000038141Danio rerio
 ATF4ENSGALG00000012135Gallus gallus
 Atf4ENSMUSG00000042406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATF5 / Q9Y2D1 / activating transcription factor 5ENSG0000016913624


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR029811  cAMP-dependent transcription factor ATF-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0032057 negative regulation of translational initiation in response to stress ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034198 cellular response to amino acid starvation ISS
 biological_processGO:0034644 cellular response to UV ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IC
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IGI
 biological_processGO:1903351 cellular response to dopamine IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 biological_processGO:1990737 response to manganese-induced endoplasmic reticulum stress IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034399 nuclear periphery IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:1990037 Lewy body core IDA
 cellular_componentGO:1990589 ATF4-CREB1 transcription factor complex IDA
 cellular_componentGO:1990590 ATF1-ATF4 transcription factor complex IDA
 cellular_componentGO:1990617 CHOP-ATF4 complex NAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IC
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043522 leucine zipper domain binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding TAS
 molecular_functionGO:0046982 protein heterodimerization activity NAS


Pathways (from Reactome)
Pathway description
ATF4 activates genes
PERK regulates gene expression
ATF6 (ATF6-alpha) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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