Manteia

ENSMUSG00000042406

Mus musculus

Features

Gene ID:	ENSMUSG00000042406

Biological name :	Atf4

Synonyms :	Atf4 / Cyclic AMP-dependent transcription factor ATF-4 / Q06507

Possible biological names infered from orthology :	activating transcription factor 4 / P18848

Species:	Mus musculus

Chr. number:	15
Strand:	1
Band:	E1
Gene start:	80255184
Gene end:	80257541

Corresponding Affymetrix probe sets:	10425364 (MoGene1.0st) 1438992_x_at (Mouse Genome 430 2.0 Array) 1439258_at (Mouse Genome 430 2.0 Array) 1448135_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000105234 Ensembl peptide - ENSMUSP00000155806 NCBI entrez gene - 11911 See in Manteia. MGI - MGI:88096 RefSeq - NM_001287180 RefSeq - NM_009716 RefSeq Peptide - NP_001274109 RefSeq Peptide - NP_033846 swissprot - Q06507 Ensembl - ENSMUSG00000042406

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
atf4a	ENSDARG00000111939	Danio rerio
atf4b	ENSDARG00000038141	Danio rerio
ATF4	ENSGALG00000012135	Gallus gallus
ATF4	ENSG00000128272	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Atf5 / O70191 / Cyclic AMP-dependent transcription factor ATF-5 / Q9Y2D1* / activating transcription factor 5*	ENSMUSG00000038539	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR004827	Basic-leucine zipper domain
IPR029811	cAMP-dependent transcription factor ATF-4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006094	gluconeogenesis	IDA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0007214	gamma-aminobutyric acid signaling pathway	IEA
biological_process	GO:0007623	circadian rhythm	IEP
biological_process	GO:0010575	positive regulation of vascular endothelial growth factor production	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0032922	circadian regulation of gene expression	IMP
biological_process	GO:0034198	cellular response to amino acid starvation	IMP
biological_process	GO:0034976	response to endoplasmic reticulum stress	IEA
biological_process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IEA
biological_process	GO:0036499	PERK-mediated unfolded protein response	IMP
biological_process	GO:0042149	cellular response to glucose starvation	IEA
biological_process	GO:0042789	mRNA transcription by RNA polymerase II	IDA
biological_process	GO:0043267	negative regulation of potassium ion transport	IEA
biological_process	GO:0043525	positive regulation of neuron apoptotic process	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048511	rhythmic process	IEA
biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP
biological_process	GO:1903204	negative regulation of oxidative stress-induced neuron death	IEA
biological_process	GO:1903351	cellular response to dopamine	IEA
biological_process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IEA
biological_process	GO:1990737	response to manganese-induced endoplasmic reticulum stress	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005667	transcription factor complex	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0032590	dendrite membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0034399	nuclear periphery	IEA
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:1990037	Lewy body core	IEA
cellular_component	GO:1990589	ATF4-CREB1 transcription factor complex	IEA
cellular_component	GO:1990590	ATF1-ATF4 transcription factor complex	IEA
cellular_component	GO:1990617	CHOP-ATF4 complex	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IEA
molecular_function	GO:0001046	core promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0001085	RNA polymerase II transcription factor binding	IEA
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008022	protein C-terminus binding	IEA
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0043522	leucine zipper domain binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	NAS

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000239	deficiency of myeloid colony forming progenitor cells	"lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Pvalb^tm1(cre)Arbr/Pvalb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000420	ruffled hair	"fuzzy, irregular appearance of the hair" [J:50844]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000422	delayed hair appearance	"late onset of the first appearance of the fur" [J:17792]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0000606	decreased hepatocyte number	"fewer than normal number of parenchymal liver cells" [J:23170]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gdnf^tm1Rosl/Gdnf^tm1Rosl Genetic Background: involves: 129S2/SvPas * CD-1
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0001322	abnormal iris morphology	"structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gdnf^tm1Rosl/Gdnf^tm1Rosl Genetic Background: involves: 129S2/SvPas * CD-1
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001606	impaired hematopoiesis	"atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Arih2^{tm1.1(KOMP)Vlcg}/Arih2⁺ Genetic Background: C57BL/6N-Arih2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0002769	abnormal vas deferens morphology	"malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0002840	abnormal lens fibers morphology	"structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki,Tg(Cryaa-Atf4)4Aki/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0003058	increased insulin secretion	"greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0003078	aphakia	"absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Arih2^{tm1.1(KOMP)Vlcg}/Arih2⁺ Genetic Background: C57BL/6N-Arih2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003383	abnormal gluconeogenesis	"anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Arih2^{tm1.1(KOMP)Vlcg}/Arih2⁺ Genetic Background: C57BL/6N-Arih2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003795	abnormal bone structure		Show Allelic Composition: Ctbp1^tm1Sor/Ctbp1^tm1Sor,Ctbp2^{Gt(ROSA61)Sor}/Ctbp2^{Gt(ROSA61)Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004064	resistance to induced muscular atrophy	"less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1f^tm1.1Sdie/Cacna1f⁺ Genetic Background: involves: C57BL/6
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Pvalb^tm1(cre)Arbr/Pvalb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005099	abnormal ciliary body morphology	"structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0005176	eyelids fail to open	"eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]	Show Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0005298	abnormal clavicle morphology	"malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0005438	abnormal glycogen homeostasis	"abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0005492	acinar hypoplasia	"decreased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss) Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: C57BL/6J * FVB
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Arih2^{tm1.1(KOMP)Vlcg}/Arih2⁺ Genetic Background: C57BL/6N-Arih2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0008794	increased lens epithelium apopotosis	"increase in the number of lens epithelial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0008907	decreased total fat pad weight	"less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009113	increased pancreatic beta cell mass	"greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009145	abnormal pancreatic acinus morphology	"any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0009146	abnormal pancreatic acinar cell morphology	"any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0009160	abnormal pancreatic acinar cell zymogen granule	"any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hivep3^tm1Glm/Hivep3^tm1Glm,Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010867	abnormal bone trabecula morphology	"any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf4^tm1Tow/Atf4⁺,Satb2^tm1Rug/Satb2⁺ Genetic Background: either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)
MP:0010875	increased bone volume	"increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf4^tm1Tow/Atf4^tm1Tow,Hivep3^tm1Glm/Hivep3^tm1Glm Genetic Background: involves: 129 * C57BL/6
MP:0010876	decreased bone volume	"reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf4^tm1Tow/Atf4⁺,Satb2^tm1Rug/Satb2⁺ Genetic Background: either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Atf4^tm1Aki/Atf4^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Notch1^tm2Agt/Notch1^tm2Agt Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0011819	increased pancreatic beta cell proliferation	"increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]	Show Allelic Composition: Il1a^tm1Yiw/Il1a^tm1Yiw,Il1b^tm1Yiw/Il1b^tm1Yiw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Arf4^{tm1b(KOMP)Wtsi}/Arf4^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Arf4^{tm1b(KOMP)Wtsi}/Ucd
MP:0020039	increased bone ossification	"increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Atf4^tm1Tow/Atf4^tm1Tow,Hivep3^tm1Glm/Hivep3^tm1Glm Genetic Background: involves: 129 * C57BL/6
MP:0020040	decreased bone ossification	"decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Atf4^tm1Tow/Atf4⁺,Satb2^tm1Rug/Satb2⁺ Genetic Background: either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)
MP:0030388	large fontanelles	"an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna]	Show Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc,Tg(Ela1-cre)16Eps/0 Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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