ENSMUSG00000038539


Mus musculus

Features
Gene ID: ENSMUSG00000038539
  
Biological name :Atf5
  
Synonyms : Atf5 / Cyclic AMP-dependent transcription factor ATF-5 / O70191
  
Possible biological names infered from orthology : activating transcription factor 5 / Q9Y2D1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44812256
Gene end: 44816658
  
Corresponding Affymetrix probe sets: 10562905 (MoGene1.0st)   1425927_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146755
Ensembl peptide - ENSMUSP00000047771
Ensembl peptide - ENSMUSP00000103525
NCBI entrez gene - 107503     See in Manteia.
MGI - MGI:2141857
RefSeq - NM_030693
RefSeq Peptide - NP_109618
swissprot - A0A140LIB7
swissprot - O70191
swissprot - Q3UJF3
Ensembl - ENSMUSG00000038539
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf5aENSDARG00000068096Danio rerio
 atf5bENSDARG00000077785Danio rerio
 ATF5ENSG00000169136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atf4 / Q06507 / Cyclic AMP-dependent transcription factor ATF-4 / P18848* / activating transcription factor 4*ENSMUSG0000004240630


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR029855  cAMP-dependent transcription factor ATF-5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021889 olfactory bulb interneuron differentiation IMP
 biological_processGO:0021891 olfactory bulb interneuron development IMP
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IMP
 biological_processGO:0021988 olfactory lobe development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046605 regulation of centrosome cycle ISS
 biological_processGO:1902750 negative regulation of cell cycle G2/M phase transition ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001003 abnormal olfactory receptor morphology "anomalous structure of the specialized proteins within the neurons of the olfactory epithelium that normally bind and detect odorants " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf5tm1(KOMP)Vlcg/Atf5tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Atf5tm1(KOMP)Vlcg/Atf5tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf5tm1(KOMP)Vlcg/Atf5tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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