50873


Mus musculus (NCBI)

Features
Gene ID: 50873
  
Biological name :
  
Synonyms : Park2 / parkin RBR E3 ubiquitin protein ligase / Prkn
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1420755_a_at (Mouse Genome 430 2.0 Array)   1426135_a_at (Mouse Genome 430 2.0 Array)   1449975_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 959241405
RefSeq - NC_000083.6
RefSeq - XP_006523399.1
RefSeq - XP_006523400.1
RefSeq - XP_006523402.1
RefSeq - XP_017173061.1
RefSeq - XP_017173062.1
RefSeq - XP_017173063.1
RefSeq - XP_017173064.1
RefSeq - XP_017173065.1
RefSeq - 1039753950
RefSeq - 1039753947
RefSeq - 1039753952
RefSeq - NP_001304655.1
RefSeq - NP_057903.1
RefSeq - 1039753954
RefSeq - 1039753958
RefSeq - 568998264
RefSeq - 568998266
RefSeq - 568998270
RefSeq - 7710078
RefSeq - XR_001782090.1
RefSeq - NM_001317726.1
RefSeq - NM_016694.4
RefSeq - XM_006523336.3
RefSeq - XM_006523337.3
RefSeq - XM_006523339.2
RefSeq - XM_017317572.1
RefSeq - XM_017317573.1
RefSeq - XM_017317574.1
RefSeq - XM_017317575.1
RefSeq - XM_017317576.1
RefSeq - XR_001782089.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000023826 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0000422 autophagy of mitochondrion ISO
 biological_processGO:0000423 mitophagy IGI
 biological_processGO:0001933 negative regulation of protein phosphorylation ISO
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0001964 startle response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0006513 protein monoubiquitination ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006986 response to unfolded protein ISO
 biological_processGO:0007612 learning IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0010498 proteasomal protein catabolic process ISO
 biological_processGO:0010506 regulation of autophagy ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010636 positive regulation of mitochondrial fusion ISO
 biological_processGO:0010821 regulation of mitochondrion organization ISO
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential ISO
 biological_processGO:0010994 free ubiquitin chain polymerization ISO
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0019538 protein metabolic process IMP
 biological_processGO:0031396 regulation of protein ubiquitination ISO
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032232 negative regulation of actin filament bundle assembly ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033132 negative regulation of glucokinase activity ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0042053 regulation of dopamine metabolic process ISO
 biological_processGO:0042415 norepinephrine metabolic process IMP
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0043388 positive regulation of DNA binding ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process ISO
 biological_processGO:0044257 cellular protein catabolic process ISO
 biological_processGO:0044828 negative regulation by host of viral genome replication ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046676 negative regulation of insulin secretion ISO
 biological_processGO:0046928 regulation of neurotransmitter secretion IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051582 positive regulation of neurotransmitter uptake ISO
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IMP
 biological_processGO:0051646 mitochondrion localization ISO
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0051881 regulation of mitochondrial membrane potential IGI
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic ISO
 biological_processGO:0060548 negative regulation of cell death ISO
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
 biological_processGO:0070534 protein K63-linked ubiquitination ISO
 biological_processGO:0070585 protein localization to mitochondrion ISO
 biological_processGO:0070842 aggresome assembly ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISO
 biological_processGO:0070979 protein K11-linked ubiquitination ISO
 biological_processGO:0085020 protein K6-linked ubiquitination ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria ISO
 biological_processGO:0090258 negative regulation of mitochondrial fission ISO
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential ISO
 biological_processGO:0097237 cellular response to toxic substance ISO
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization ISO
 biological_processGO:0099074 mitochondrion to lysosome transport ISO
 biological_processGO:1900407 regulation of cellular response to oxidative stress ISO
 biological_processGO:1901215 negative regulation of neuron death ISO
 biological_processGO:1901526 positive regulation of mitophagy ISO
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process ISO
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:1902283 negative regulation of primary amine oxidase activity ISO
 biological_processGO:1902530 positive regulation of protein linear polyubiquitination ISO
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death ISO
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
 biological_processGO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process ISO
 biological_processGO:1903542 negative regulation of exosomal secretion ISO
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion ISO
 biological_processGO:1903861 positive regulation of dendrite extension IGI
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion ISO
 biological_processGO:1904881 cellular response to hydrogen sulfide ISO
 biological_processGO:1905232 cellular response to L-glutamate ISO
 biological_processGO:1905366 negative regulation of intralumenal vesicle formation ISO
 biological_processGO:1905477 positive regulation of protein localization to membrane ISO
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2001171 positive regulation of ATP biosynthetic process ISO
 cellular_componentGO:0000139 Golgi membrane ISO
 cellular_componentGO:0000151 ubiquitin ligase complex ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle ISO
 cellular_componentGO:0014069 postsynaptic density ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030672 synaptic vesicle membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0043195 terminal bouton ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0071797 LUBAC complex ISO
 cellular_componentGO:0098793 presynapse ISO
 cellular_componentGO:0099073 mitochondrion-derived vesicle ISO
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0015631 tubulin binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding ISO
 molecular_functionGO:0031072 heat shock protein binding ISO
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISO
 molecular_functionGO:0043274 phospholipase binding ISO
 molecular_functionGO:0044877 protein-containing complex binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO
 molecular_functionGO:0097602 cullin family protein binding ISO
 molecular_functionGO:1990381 ubiquitin-specific protease binding ISO
 molecular_functionGO:1990444 F-box domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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