ENSMUSG00000023826


Mus musculus

Features
Gene ID: ENSMUSG00000023826
  
Biological name :Park2
  
Synonyms : E3 ubiquitin-protein ligase parkin / Park2 / Q9WVS6
  
Possible biological names infered from orthology : O60260 / parkin RBR E3 ubiquitin protein ligase / PRKN
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 10840384
Gene end: 12063361
  
Corresponding Affymetrix probe sets: 10441718 (MoGene1.0st)   1420755_a_at (Mouse Genome 430 2.0 Array)   1426135_a_at (Mouse Genome 430 2.0 Array)   1449975_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127455
Ensembl peptide - ENSMUSP00000140217
Ensembl peptide - ENSMUSP00000140587
Ensembl peptide - ENSMUSP00000151830
Ensembl peptide - ENSMUSP00000136268
NCBI entrez gene - 50873     See in Manteia.
MGI - MGI:1355296
RefSeq - XM_017317575
RefSeq - NM_016694
RefSeq - XM_006523336
RefSeq - XM_006523337
RefSeq - XM_006523339
RefSeq - XM_017317572
RefSeq - XM_017317573
RefSeq - XM_017317574
RefSeq - NM_001317726
RefSeq Peptide - NP_001304655
RefSeq Peptide - NP_057903
swissprot - A0A1W2P7W2
swissprot - F6TNF2
swissprot - A0A087WQJ2
swissprot - Q9WVS6
swissprot - J3QMF8
Ensembl - ENSMUSG00000023826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prknENSDARG00000021555Danio rerio
 PRKNENSGALG00000011562Gallus gallus
 PRKNENSG00000185345Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR002867  IBR domain
 IPR003977  E3 ubiquitin-protein ligase parkin
 IPR029071  Ubiquitin-like domain superfamily
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000266 mitochondrial fission ISS
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0000423 mitophagy IGI
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0001964 startle response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0007005 mitochondrion organization ISS
 biological_processGO:0007612 learning IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010636 positive regulation of mitochondrial fusion IEA
 biological_processGO:0010637 negative regulation of mitochondrial fusion ISS
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0010994 free ubiquitin chain polymerization IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019538 protein metabolic process IMP
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032232 negative regulation of actin filament bundle assembly IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033132 negative regulation of glucokinase activity IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042415 norepinephrine metabolic process IMP
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044257 cellular protein catabolic process IMP
 biological_processGO:0044828 negative regulation by host of viral genome replication IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046329 negative regulation of JNK cascade ISS
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051582 positive regulation of neurotransmitter uptake IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IMP
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IGI
 biological_processGO:0055069 zinc ion homeostasis ISS
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0070050 neuron cellular homeostasis ISS
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070585 protein localization to mitochondrion IMP
 biological_processGO:0070842 aggresome assembly IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0070979 protein K11-linked ubiquitination IEA
 biological_processGO:0085020 protein K6-linked ubiquitination IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090141 positive regulation of mitochondrial fission ISS
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097237 cellular response to toxic substance IDA
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0099074 mitochondrion to lysosome transport IEA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1902283 negative regulation of primary amine oxidase activity IEA
 biological_processGO:1902530 positive regulation of protein linear polyubiquitination IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903542 negative regulation of exosomal secretion IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903861 positive regulation of dendrite extension IGI
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion IEA
 biological_processGO:1905366 negative regulation of intralumenal vesicle formation IEA
 biological_processGO:1905477 positive regulation of protein localization to membrane IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071797 LUBAC complex IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0099073 mitochondrion-derived vesicle IEA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0097602 cullin family protein binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA
 molecular_functionGO:1990444 F-box domain binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Josephin domain DUBs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1tm3Itan/Runx1tm3Itan
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dscam3J/Dscam3J
Genetic Background: involves: C3H/HeSnSmn * CB17

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Sostdc1shk/Sostdc1shk
Genetic Background: involves: C57BL/6J * CAST/EiJ * NOD

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sostdc1shk/Sostdc1shk
Genetic Background: involves: C57BL/6J * CAST/EiJ * NOD

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CrygbS11R/CrygbS11R,Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: A/J * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(CAG-SNCA*)1.1Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(PDGFB-GPR37)20Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(CAG-SNCA*)1.1Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(CAG-SNCA*)1.1Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(CAG-SNCA*)1.1Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(CAG-SNCA*)1.1Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Prkntm2Tmd/Prkntm2Tmd
Genetic Background: Not Specified

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0011975 neuronal cytoplasmic inclusions "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014046 abnormal mitophagy "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J

 MP:0020543 decreased substantia nigra size "decreased size of the substantia nigra" [MGI:smb]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028756 Pink1 / Q99MQ3 / Serine/threonine-protein kinase PINK1, mitochondrial / Q9BXM7* / PTEN induced putative kinase 1*  / reaction / complex






 

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