ENSGALG00000011562


Gallus gallus

Features
Gene ID: ENSGALG00000011562
  
Biological name :PRKN
  
Synonyms : parkin RBR E3 ubiquitin protein ligase / PRKN
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase parkin / O60260 / Park2 / Q9WVS6
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 44611057
Gene end: 45288689
  
Corresponding Affymetrix probe sets: GgaAffx.23587.1.S1_at (Chicken Array)   GgaAffx.7323.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018834
NCBI entrez gene - 421577     See in Manteia.
RefSeq - XM_419615
swissprot - F1NWU0
Ensembl - ENSGALG00000011562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prknENSDARG00000021555Danio rerio
 PRKNENSG00000185345Homo sapiens
 Park2ENSMUSG00000023826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR002867  IBR domain
 IPR003977  E3 ubiquitin-protein ligase parkin
 IPR029071  Ubiquitin-like domain superfamily
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0000423 mitophagy IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010636 positive regulation of mitochondrial fusion IEA
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0010994 free ubiquitin chain polymerization IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019538 protein metabolic process IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032232 negative regulation of actin filament bundle assembly IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033132 negative regulation of glucokinase activity IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042415 norepinephrine metabolic process IEA
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0044828 negative regulation by host of viral genome replication IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051582 positive regulation of neurotransmitter uptake IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070585 protein localization to mitochondrion IEA
 biological_processGO:0070842 aggresome assembly IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0070979 protein K11-linked ubiquitination IEA
 biological_processGO:0085020 protein K6-linked ubiquitination IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0099074 mitochondrion to lysosome transport IEA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1902283 negative regulation of primary amine oxidase activity IEA
 biological_processGO:1902530 positive regulation of protein linear polyubiquitination IEA
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903542 negative regulation of exosomal secretion IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion IEA
 biological_processGO:1905366 negative regulation of intralumenal vesicle formation IEA
 biological_processGO:1905477 positive regulation of protein localization to membrane IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071797 LUBAC complex IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0099073 mitochondrion-derived vesicle IEA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0097602 cullin family protein binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA
 molecular_functionGO:1990444 F-box domain binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Josephin domain DUBs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010766 ATXN3 / Q9W689 / Ataxin-3 / ATXN3L* / P54252* / Q9CVD2* / Q9H3M9* / ataxin 3 like*  / reaction / complex
 ENSGALG00000037593 PINK1 / PTEN induced putative kinase 1 / Q99MQ3* / Q9BXM7* / Serine/threonine-protein kinase PINK1, mitochondrial *  / complex / reaction






 

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