ENSDARG00000021555


Danio rerio

Features
Gene ID: ENSDARG00000021555
  
Biological name :prkn
  
Synonyms : parkin RBR E3 ubiquitin protein ligase / prkn
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase parkin / O60260 / Park2 / Q9WVS6
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 3354895
Gene end: 3516473
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000033749
Ensembl peptide - ENSDARP00000141580
Ensembl peptide - ENSDARP00000116733
NCBI entrez gene - 550328     See in Manteia.
RefSeq - NM_001017635
RefSeq Peptide - NP_001017635
swissprot - A5WUG4
swissprot - A0A0H2UKX4
swissprot - F1Q9C4
ZFIN ID - ZDB-GENE-050417-109
Ensembl - ENSDARG00000021555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKNENSGALG00000011562Gallus gallus
 PRKNENSG00000185345Homo sapiens
 Park2ENSMUSG00000023826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR002867  IBR domain
 IPR003977  E3 ubiquitin-protein ligase parkin
 IPR029071  Ubiquitin-like domain superfamily
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006120 mitochondrial electron transport, NADH to ubiquinone IMP
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0009266 response to temperature stimulus IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0051865 protein autoubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Josephin domain DUBs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000633 caudal tuberculum caudal tuberculum dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell T-tubule unlumenized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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