ENSMUSG00000028756


Mus musculus

Features
Gene ID: ENSMUSG00000028756
  
Biological name :Pink1
  
Synonyms : Pink1 / Q99MQ3 / Serine/threonine-protein kinase PINK1, mitochondrial
  
Possible biological names infered from orthology : PTEN induced putative kinase 1 / Q9BXM7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 138313409
Gene end: 138326307
  
Corresponding Affymetrix probe sets: 10517600 (MoGene1.0st)   1441937_s_at (Mouse Genome 430 2.0 Array)   1451148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030536
Ensembl peptide - ENSMUSP00000101443
Ensembl peptide - ENSMUSP00000101442
NCBI entrez gene - 68943     See in Manteia.
MGI - MGI:1916193
RefSeq - NM_026880
RefSeq Peptide - NP_081156
swissprot - A2AM78
swissprot - A2AM76
swissprot - Q99MQ3
Ensembl - ENSMUSG00000028756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pink1ENSDARG00000001929Danio rerio
 PINK1ENSGALG00000037593Gallus gallus
 PINK1ENSG00000158828Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002082 regulation of oxidative phosphorylation IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0016242 negative regulation of macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IMP
 biological_processGO:0033605 positive regulation of catecholamine secretion IMP
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0035307 positive regulation of protein dephosphorylation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:0090141 positive regulation of mitochondrial fission IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0090258 negative regulation of mitochondrial fission IEA
 biological_processGO:0097237 cellular response to toxic substance IMP
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0099074 mitochondrion to lysosome transport IEA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901727 positive regulation of histone deacetylase activity IMP
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 biological_processGO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
 biological_processGO:1903147 negative regulation of autophagy of mitochondrion IEA
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death IEA
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IEA
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IEA
 biological_processGO:1903852 positive regulation of cristae formation IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1904783 positive regulation of NMDA glutamate receptor activity IEA
 biological_processGO:1904881 cellular response to hydrogen sulfide IEA
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005742 mitochondrial outer membrane translocase complex IEA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0031932 TORC2 complex IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0010857 calcium-dependent protein kinase activity IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Blh/?
Genetic Background: involves: C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1(GFP)Imku/?,Zfp335blt/Zfp335blt
Genetic Background: involves: C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Blh/?
Genetic Background: involves: C57BL/6

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Blh/?
Genetic Background: involves: C57BL/6

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1(GFP)Imku/?,Zfp335blt/Zfp335blt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst,Tg(Prnp-SNCA*A53T)AAub/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm2.1Snj/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst,Tg(Prnp-SNCA*A53T)AAub/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm2.1Snj/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pink1tm1Vbae/Pink1tm1Vbae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003908 decreased stereotypic behavior "less frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

Allelic Composition: Pink1tm1Hlw/Pink1tm1Hlw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst,Tg(Prnp-SNCA*A53T)AAub/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

Allelic Composition: Park7Gt(XE726)Byg/Park7Gt(XE726)Byg,Pink1tm1.1Wrst/Pink1tm1.1Wrst,Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

Allelic Composition: Pink1tm1Zhzh/Pink1tm1Zhzh,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pink1tm1Vbae/Pink1tm1Vbae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst,Tg(Prnp-SNCA*A53T)AAub/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

Allelic Composition: Park7Gt(XE726)Byg/Park7Gt(XE726)Byg,Pink1tm1.1Wrst/Pink1tm1.1Wrst,Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pink1tm1Hlw/Pink1tm1Hlw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
Show

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Lpk/Col2a1+
Genetic Background: either: C3H.Cg-Col2a1Lpk/H or (involves: C3H/HeH * C57BL/6J)

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

 MP:0011975 neuronal cytoplasmic inclusions "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk]
Show

Allelic Composition: Pink1tm1Zhzh/Pink1tm1Zhzh,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023826 Park2 / Q9WVS6 / E3 ubiquitin-protein ligase parkin / PRKN* / O60260* / parkin RBR E3 ubiquitin protein ligase*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr