54209


Homo sapiens (NCBI)
regulationresponsebindingsignalingimmunedetectionpeptidoglycanlipoteichoicacidmembraneantigendifferentiationlipopolysaccharideerkcellularproteinplasmareceptorpathwayprocessingpresentationpeptideviamhcclassiiphagocytosisengulfmenthumoralsignal

Features
Gene ID: 54209
  
Biological name :
  
Synonyms : TREM2 / TREM-2|Trem2a|Trem2b|Trem2c / triggering receptor expressed on myeloid cells 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 219725_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 425876764
RefSeq - 9507203
RefSeq - NC_000006.12
RefSeq - NG_011561.1
RefSeq - NP_001258750.1
RefSeq - NP_061838.1
RefSeq - NM_001271821.1
RefSeq - NM_018965.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000095970 to get all the annotations available for this gene.


Gene Ontology (GO)
antigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigen processing and presentationcellular component organizationestablishment of localizationimmune responsecell communicationcellular response to stimulusanatomical structure developmentcellular developmental processresponse to external stimulusresponse to chemicalresponse to biotic stimulusdetection of stimulusresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to endogenous stimulusmacromolecule localizationcellular localizationantigenantigen processing and presentationcellulacellular component organizationestabliestablishment of localizationimmune immune responsecell cocell communicationcellulacellular response to stimulusanatomianatomical structure developmentcellulacellular developmental processresponsresponse to external stimulusresponsresponse to chemicalresponsresponse to biotic stimulusdetectidetection of stimulusresponsresponse to stressnitrogenitrogen compound metabolic processcellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processresponsresponse to endogenous stimulusmacromomacromolecule localizationcellulacellular localization
lipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingion bindingsignaling receptor activityprotein bindinglipid bindinglipid bindingcarbohydrate derivative bindcarbohydrate derivative bindingion bindingion bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
extracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regionextracellular regioncellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0032497 detection of lipopolysaccharide IEA
 biological_processGO:0032499 detection of peptidoglycan IEA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070392 detection of lipoteichoic acid IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071224 cellular response to peptidoglycan IEA
 biological_processGO:0097028 dendritic cell differentiation IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway IDA
 biological_processGO:2000350 positive regulation of CD40 signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016021 integral component of membrane IDA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0038023 signaling receptor activity TAS
 molecular_functionGO:0042834 peptidoglycan binding IEA
 molecular_functionGO:0070891 lipoteichoic acid binding IEA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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