5594


Homo sapiens (NCBI)

Features
Gene ID: 5594
  
Biological name :
  
Synonyms : ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK / MAPK1 / mitogen-activated protein kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1552263_at (Human Genome U133 Plus 2.0 Array)   1552264_a_at (Human Genome U133 Plus 2.0 Array)   208351_s_at (Human Genome U133 Plus 2.0 Array)   212271_at (Human Genome U133 Plus 2.0 Array)   224620_at (Human Genome U133 Plus 2.0 Array)   224621_at (Human Genome U133 Plus 2.0 Array)   229847_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 20986531
RefSeq - 66932916
RefSeq - NC_000022.11
RefSeq - NG_023054.2
RefSeq - NP_002736.3
RefSeq - NP_620407.1
RefSeq - NM_002745.4
RefSeq - NM_138957.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000100030 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007611 learning or memory NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0015966 diadenosine tetraphosphate biosynthetic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019858 cytosine metabolic process IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030641 regulation of cellular pH IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032872 regulation of stress-activated MAPK cascade TAS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0035094 response to nicotine ISS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0038127 ERBB signaling pathway IDA
 biological_processGO:0042473 outer ear morphogenesis IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade TAS
 biological_processGO:0070849 response to epidermal growth factor IDA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072584 caveolin-mediated endocytosis TAS
 biological_processGO:0090170 regulation of Golgi inheritance TAS
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1903351 cellular response to dopamine IMP
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:2000641 regulation of early endosome to late endosome transport TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005925 focal adhesion TAS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity TAS
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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