5728


Homo sapiens (NCBI)

Features
Gene ID: 5728
  
Biological name :
  
Synonyms : 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|PTENbeta|TEP1 / phosphatase and tensin homolog / PTEN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 204053_x_at (Human Genome U133 Plus 2.0 Array)   204054_at (Human Genome U133 Plus 2.0 Array)   211711_s_at (Human Genome U133 Plus 2.0 Array)   217492_s_at (Human Genome U133 Plus 2.0 Array)   225363_at (Human Genome U133 Plus 2.0 Array)   227469_at (Human Genome U133 Plus 2.0 Array)   228006_at (Human Genome U133 Plus 2.0 Array)   233254_x_at (Human Genome U133 Plus 2.0 Array)   242622_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 73765544
RefSeq - 754502064
RefSeq - 799322616
RefSeq - NC_000010.11
RefSeq - NG_007466.2
RefSeq - NP_001291646.2
RefSeq - NP_001291647.1
RefSeq - NW_013171807.1
RefSeq - NP_000305.3
RefSeq - NM_000314.6
RefSeq - NM_001304717.2
RefSeq - NM_001304718.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000171862 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0002902 regulation of B cell apoptotic process IEA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007270 neuron-neuron synaptic transmission ISS
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007417 central nervous system development ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0007613 memory IEA
 biological_processGO:0007626 locomotory behavior ISS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0010975 regulation of neuron projection development ISS
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0021542 dentate gyrus development ISS
 biological_processGO:0021955 central nervous system neuron axonogenesis ISS
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0031642 negative regulation of myelination IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032286 central nervous system myelin maintenance ISS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032535 regulation of cellular component size ISS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033032 regulation of myeloid cell apoptotic process IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0033555 multicellular organismal response to stress ISS
 biological_processGO:0035176 social behavior ISS
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling ISS
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0045475 locomotor rhythm ISS
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045792 negative regulation of cell size ISS
 biological_processGO:0046621 negative regulation of organ growth ISS
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IDA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0048853 forebrain morphogenesis ISS
 biological_processGO:0048854 brain morphogenesis ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050771 negative regulation of axonogenesis ISS
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051548 negative regulation of keratinocyte migration IMP
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:0060024 rhythmic synaptic transmission ISS
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060074 synapse maturation ISS
 biological_processGO:0060134 prepulse inhibition ISS
 biological_processGO:0060179 male mating behavior IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0060736 prostate gland growth IEA
 biological_processGO:0060997 dendritic spine morphogenesis ISS
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071257 cellular response to electrical stimulus IMP
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090071 negative regulation of ribosome biogenesis IEA
 biological_processGO:0090344 negative regulation of cell aging IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential ISS
 biological_processGO:0097105 presynaptic membrane assembly ISS
 biological_processGO:0097107 postsynaptic density assembly ISS
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IMP
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway IMP
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IDA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IDA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA
 biological_processGO:2000272 negative regulation of signaling receptor activity IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000808 negative regulation of synaptic vesicle clustering ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IMP
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region ISS
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure ISS
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IPI
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TAS
 molecular_functionGO:1990381 ubiquitin-specific protease binding IPI
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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