6259


Homo sapiens (NCBI)
kinasepathwayactivitysignalingneuronproteinregulationwntbindingaxoncelldifferentiationmembranereceptordevelopmentguidancemidbraindopaminergicinvolvedsignaltransductioncascadeerkplanarpolarityplasmaintegralcomponenttyrosinetransmembrane

Features
Gene ID: 6259
  
Biological name :
  
Synonyms : D3S3195|JTK5|JTK5A|RYK1 / receptor-like tyrosine kinase / RYK
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 202853_s_at (Human Genome U133 Plus 2.0 Array)   214172_x_at (Human Genome U133 Plus 2.0 Array)   216976_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NP_001005861.1
RefSeq - NP_002949.2
RefSeq - 54607018
RefSeq - NG_032937.1
RefSeq - 54607020
RefSeq - NC_000003.12
RefSeq - XR_924160.2
RefSeq - NM_001005861.2
RefSeq - NM_002958.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000163785 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular developmental processresponse to external stimulusresponse to chemicalmovement of cell or subcellular componentcellular component biogenesisneural precursor cell proliferationregulation of molecular functioncell deathnitrogennitrogen compound metabolic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processcell comcell communicationcellularcellular response to stimulusanatomicanatomical structure developmentcellularcellular component organizationcellularcellular developmental processresponseresponse to external stimulusresponseresponse to chemicalmovementmovement of cell or subcellular componentcellularcellular component biogenesisneural pneural precursor cell proliferationregulatiregulation of molecular functioncell deacell death
catalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activitysignaling recesignaling receptor activityprotein bindinprotein bindingion bindingion bindingcarbohydrate dcarbohydrate derivative bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingdrug bindingdrug binding
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007409 axonogenesis TAS
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0007416 synapse assembly NAS
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0022008 neurogenesis NAS
 biological_processGO:0022038 corpus callosum development ISS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0033278 cell proliferation in midbrain ISS
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0035567 non-canonical Wnt signaling pathway NAS
 biological_processGO:0036518 chemorepulsion of dopaminergic neuron axon ISS
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0060070 canonical Wnt signaling pathway NAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071679 commissural neuron axon guidance ISS
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance ISS
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation ISS
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0043235 receptor complex IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005109 frizzled binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0017147 Wnt-protein binding NAS
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity ISS
 molecular_functionGO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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