66725


Mus musculus (NCBI)

Features
Gene ID: 66725
  
Biological name :
  
Synonyms : 4921513O20Rik|9330188B09Rik|AW561911|D630001M17Rik|Gm927|cI-46 / leucine-rich repeat kinase 2 / Lrrk2
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1431394_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 146231954
RefSeq - 568993083
RefSeq - NC_000081.6
RefSeq - NP_080006.3
RefSeq - XP_006521340.1
RefSeq - XM_006521277.3
RefSeq - XR_875310.2
RefSeq - NM_025730.3
RefSeq - XR_001781561.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000036273 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0000186 activation of MAPKK activity ISO
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007005 mitochondrion organization ISO
 biological_processGO:0007030 Golgi organization ISO
 biological_processGO:0007040 lysosome organization ISO
 biological_processGO:0007528 neuromuscular junction development ISO
 biological_processGO:0008340 determination of adult lifespan ISO
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010506 regulation of autophagy ISO
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0010738 regulation of protein kinase A signaling IMP
 biological_processGO:0010955 negative regulation of protein processing ISO
 biological_processGO:0010977 negative regulation of neuron projection development ISO
 biological_processGO:0014041 regulation of neuron maturation ISO
 biological_processGO:0016242 negative regulation of macroautophagy ISO
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0021772 olfactory bulb development ISO
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IMP
 biological_processGO:0034260 negative regulation of GTPase activity ISO
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0035564 regulation of kidney size IMP
 biological_processGO:0035640 exploration behavior ISO
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0035751 regulation of lysosomal lumen pH ISO
 biological_processGO:0036465 synaptic vesicle recycling TAS
 biological_processGO:0040012 regulation of locomotion ISO
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0043068 positive regulation of programmed cell death ISO
 biological_processGO:0046039 GTP metabolic process ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048312 intracellular distribution of mitochondria ISO
 biological_processGO:0048812 neuron projection morphogenesis ISO
 biological_processGO:0051646 mitochondrion localization ISO
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISO
 biological_processGO:0051900 regulation of mitochondrial depolarization ISO
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway IMP
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway ISO
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IPI
 biological_processGO:0061001 regulation of dendritic spine morphogenesis ISO
 biological_processGO:0070997 neuron death ISO
 biological_processGO:0071287 cellular response to manganese ion ISO
 biological_processGO:0072593 reactive oxygen species metabolic process ISO
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IMP
 biological_processGO:0140058 neuron projection arborization ISO
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis ISO
 biological_processGO:1901214 regulation of neuron death ISO
 biological_processGO:1901215 negative regulation of neuron death ISO
 biological_processGO:1901727 positive regulation of histone deacetylase activity IMP
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1902499 positive regulation of protein autoubiquitination ISO
 biological_processGO:1902692 regulation of neuroblast proliferation ISO
 biological_processGO:1902803 regulation of synaptic vesicle transport IMP
 biological_processGO:1902902 negative regulation of autophagosome assembly ISO
 biological_processGO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation ISO
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death ISO
 biological_processGO:1903215 negative regulation of protein targeting to mitochondrion ISO
 biological_processGO:1903351 cellular response to dopamine ISO
 biological_processGO:1903980 positive regulation of microglial cell activation ISO
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion ISO
 biological_processGO:1904887 Wnt signalosome assembly ISO
 biological_processGO:1905279 regulation of retrograde transport, endosome to Golgi ISO
 biological_processGO:1905289 regulation of CAMKK-AMPK signaling cascade ISO
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve ISO
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005798 Golgi-associated vesicle ISO
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016234 inclusion body ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030425 dendrite ISO
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031966 mitochondrial membrane ISO
 cellular_componentGO:0032473 cytoplasmic side of mitochondrial outer membrane ISO
 cellular_componentGO:0032839 dendrite cytoplasm ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0043195 terminal bouton IC
 cellular_componentGO:0043204 perikaryon ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0044753 amphisome ISO
 cellular_componentGO:0044754 autolysosome ISO
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0097487 multivesicular body, internal vesicle ISO
 cellular_componentGO:0099400 caveola neck ISO
 cellular_componentGO:1990904 ribonucleoprotein complex IDA
 cellular_componentGO:1990909 Wnt signalosome ISO
 molecular_functionGO:0000149 SNARE binding ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004708 MAP kinase kinase activity ISO
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0015631 tubulin binding ISO
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding ISO
 molecular_functionGO:0017075 syntaxin-1 binding ISO
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IC
 molecular_functionGO:0030276 clathrin binding ISO
 molecular_functionGO:0034211 GTP-dependent protein kinase activity ISO
 molecular_functionGO:0036479 peroxidase inhibitor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IC
 molecular_functionGO:0051018 protein kinase A binding ISO
 molecular_functionGO:1904713 beta-catenin destruction complex binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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