7046


Homo sapiens (NCBI)

Features
Gene ID: 7046
  
Biological name :
  
Synonyms : AAT5|ACVRLK4|ALK-5|ALK5|ESS1|LDS1|LDS1A|LDS2A|MSSE|SKR4|TBR-i|TBRI|TGFR-1|tbetaR-I / TGFBR1 / transforming growth factor beta receptor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 206943_at (Human Genome U133 Plus 2.0 Array)   224793_s_at (Human Genome U133 Plus 2.0 Array)   236561_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_024303426.1
RefSeq - 1370515024
RefSeq - 195963412
RefSeq - 4759226
RefSeq - 767958123
RefSeq - 767958125
RefSeq - 767958127
RefSeq - 817050443
RefSeq - NC_000009.12
RefSeq - NG_007461.1
RefSeq - NP_001124388.1
RefSeq - NP_001293139.1
RefSeq - NP_004603.1
RefSeq - XP_011517250.1
RefSeq - XP_011517251.1
RefSeq - XP_011517252.1
RefSeq - XP_016870552.1
RefSeq - 1034671121
RefSeq - NM_001130916.2
RefSeq - NM_001306210.1
RefSeq - NM_004612.3
RefSeq - XM_011518950.2
RefSeq - XM_017015063.1
RefSeq - XM_024447658.1
RefSeq - XM_011518948.2
RefSeq - XM_011518949.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000106799 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001501 skeletal system development ISS
 biological_processGO:0001701 in utero embryonic development ISS
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis ISS
 biological_processGO:0003223 ventricular compact myocardium morphogenesis ISS
 biological_processGO:0003342 proepicardium development ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007389 pattern specification process IBA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008354 germ cell migration ISS
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009952 anterior/posterior pattern specification ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0030199 collagen fibril organization ISS
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation ISS
 biological_processGO:0032924 activin receptor signaling pathway ISS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0042118 endothelial cell activation ISS
 biological_processGO:0043062 extracellular structure organization TAS
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048538 thymus development ISS
 biological_processGO:0048663 neuron fate commitment ISS
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis ISS
 biological_processGO:0048705 skeletal system morphogenesis ISS
 biological_processGO:0048762 mesenchymal cell differentiation TAS
 biological_processGO:0048844 artery morphogenesis ISS
 biological_processGO:0048870 cell motility IMP
 biological_processGO:0051272 positive regulation of cellular component movement IMP
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060017 parathyroid gland development ISS
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060037 pharyngeal system development ISS
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation ISS
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition ISS
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IDA
 biological_processGO:0060412 ventricular septum morphogenesis ISS
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis ISS
 biological_processGO:0060982 coronary artery morphogenesis ISS
 biological_processGO:0070723 response to cholesterol IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:1905075 positive regulation of occluding junction disassembly ISS
 biological_processGO:1905223 epicardium morphogenesis ISS
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048179 activin receptor complex IBA
 cellular_componentGO:0070022 transforming growth factor beta receptor complex IC
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity IMP
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I IDA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0019838 growth factor binding IPI
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IBA
 molecular_functionGO:0050431 transforming growth factor beta binding IPI
 molecular_functionGO:0070411 I-SMAD binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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