7486


Homo sapiens (NCBI)

Features
Gene ID: 7486
  
Biological name :
  
Synonyms : RECQ3|RECQL2|RECQL3 / Werner syndrome RecQ like helicase / WRN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 205667_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NC_000008.11
RefSeq - XP_011542941.1
RefSeq - XP_011542942.1
RefSeq - XP_024303033.1
RefSeq - NG_008870.1
RefSeq - 1370512850
RefSeq - 110735439
RefSeq - NP_000544.2
RefSeq - 767951190
RefSeq - 767951195
RefSeq - XR_949472.3
RefSeq - NM_000553.5
RefSeq - XM_011544639.3
RefSeq - XM_011544640.1
RefSeq - XM_024447265.1
RefSeq - XR_949470.3
RefSeq - XR_949471.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000165392 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance TAS
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IDA
 biological_processGO:0001302 replicative cell aging IEA
 biological_processGO:0006259 DNA metabolic process IDA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006284 base-excision repair IDA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006310 DNA recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging NAS
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008340 determination of adult lifespan IBA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010225 response to UV-C IDA
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0032508 DNA duplex unwinding IDA
 biological_processGO:0040009 regulation of growth rate IEA
 biological_processGO:0042981 regulation of apoptotic process IGI
 biological_processGO:0044806 G-quadruplex DNA unwinding ISS
 biological_processGO:0051345 positive regulation of hydrolase activity IDA
 biological_processGO:0061820 telomeric D-loop disassembly TAS
 biological_processGO:0071480 cellular response to gamma radiation IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090656 t-circle formation TAS
 biological_processGO:0098530 positive regulation of strand invasion IDA
 biological_processGO:1902570 protein localization to nucleolus IDA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork ISS
 cellular_componentGO:0005662 DNA replication factor A complex IBA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0032389 MutLalpha complex IDA
 cellular_componentGO:0035861 site of double-strand break IBA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0000403 Y-form DNA binding IDA
 molecular_functionGO:0000405 bubble DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003678 DNA helicase activity IMP
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IDA
 molecular_functionGO:0004386 helicase activity IDA
 molecular_functionGO:0004527 exonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IDA
 molecular_functionGO:0009378 four-way junction helicase activity IDA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0030145 manganese ion binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IDA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0051880 G-quadruplex DNA binding IDA
 molecular_functionGO:0061749 forked DNA-dependent helicase activity IDA
 molecular_functionGO:0061821 telomeric D-loop binding IDA
 molecular_functionGO:0061849 telomeric G-quadruplex DNA binding IC
 molecular_functionGO:0070337 3"-flap-structured DNA binding IDA
 molecular_functionGO:1905773 8-hydroxy-2"-deoxyguanosine DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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