ENSDARG00000002593


Danio rerio

Features
Gene ID: ENSDARG00000002593
  
Biological name :slc45a2
  
Synonyms : slc45a2 / solute carrier family 45, member 2
  
Possible biological names infered from orthology : P58355 / Q9UMX9
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 19445942
Gene end: 19484289
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000038893
NCBI entrez gene - 558311     See in Manteia.
RefSeq - NM_001110377
RefSeq Peptide - NP_001103847
swissprot - F1QUJ8
ZFIN ID - ZDB-GENE-050208-97
Ensembl - ENSDARG00000002593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC45A2ENSGALG00000003310Gallus gallus
 Q9UMX9ENSG00000164175Homo sapiens
 P58355ENSMUSG00000022243Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slc45a1 / solute carrier family 45, member 1 / Q8BIV7* / Q9Y2W3* / Proton-associated sugar transporter A *ENSDARG0000000430239
slc45a4 / solute carrier family 45, member 4 / Q0P5V9* / Q5BKX6* / Mus musculus solute carrier family 45, member 4 (Slc45a4), transcript variant 3, mRNA.*ENSDARG0000007732636
SLC45A4 (1 of many) / solute carrier family 45 member 4 / Q5BKX6* / SLC45A4*ENSDARG0000010498125
zgc:77158ENSDARG0000001378422
slc45a3 / solute carrier family 45, member 3 / Q8K0H7* / Q96JT2*ENSDARG0000007597520


Protein motifs (from Interpro)
Interpro ID Name
 IPR020846  Major facilitator superfamily domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Melanin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta vascular endothelium decreased amount , abnormal
Show

 ZFA:0000035 lens lens radical increased amount , abnormal
lens cellular oxidant detoxification disrupted , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000076 swim bladder swim bladder epithelium increased thickness , abnormal
swim bladder epithelium surrounded by fibroblast , abnormal
swim bladder epithelial cell morphology , abnormal
swim bladder epithelial cell has extra parts of type neutrophil , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye morphology , abnormal
Show

 ZFA:0000114 heart heart elongated , abnormal
heart edematous , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell proliferation decreased process quality , abnormal
retinal inner nuclear layer cell proliferation increased occurrence , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium unpigmented , abnormal
retinal pigmented epithelium decreased pigmentation , abnormal
retinal pigmented epithelium melanosome decreased pigmentation , abnormal
retinal pigmented epithelium quality , abnormal
retinal pigmented epithelium reflectivity , abnormal
Show

 ZFA:0000152 retina retina regeneration process quality , abnormal
retina decreased distribution , abnormal
retina apoptotic process increased occurrence , abnormal
retina decreased pigmentation , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein fused with dorsal aorta , abnormal
Show

 ZFA:0001058 caudal fin caudal fin lacks parts or has fewer parts of type nucleate erythrocyte , abnormal
caudal fin elongated , abnormal
Show

 ZFA:0001094 whole organism whole organism colorless , abnormal
whole organism curved ventral , abnormal
whole organism decreased life span , abnormal
whole organism life span , ameliorated
whole organism decreased pigmentation , abnormal
whole organism lacks all parts of type melanocyte , abnormal
whole organism Melanin decreased amount , abnormal
whole organism dead , abnormal
Show

 ZFA:0001115 trunk trunk blood vessel endothelial cell mislocalised , abnormal
Show

 ZFA:0001127 visual system visual system decreased functionality , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel has extra parts of type endothelial cell , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel angiogenic sprout decreased length , abnormal
intersegmental vessel angiogenic sprout decreased amount , abnormal
intersegmental vessel decreased length , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus morphology , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe melanocyte absent , abnormal
melanophore stripe absent , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer cell proliferation decreased process quality , abnormal
retinal outer nuclear layer morphology , abnormal
retinal outer nuclear layer decreased thickness , abnormal
retinal outer nuclear layer has fewer parts of type green sensitive photoreceptor cell , abnormal
retinal outer nuclear layer has fewer parts of type red sensitive photoreceptor cell , abnormal
retinal outer nuclear layer apoptotic process increased process quality , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer morphology , abnormal
photoreceptor outer segment layer disorganized , abnormal
Show

 ZFA:0001605 caudal fin lower lobe caudal fin lower lobe elongated , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel absent , abnormal
dorsal longitudinal anastomotic vessel aplastic , abnormal
Show

 ZFA:0005220 larval melanophore stripe larval melanophore stripe melanocyte absent , abnormal
larval melanophore stripe melanocyte decreased amount , abnormal
Show

 ZFA:0005314 blood vessel blood vessel decreased area , abnormal
Show

 ZFA:0005604 angiogenic sprout angiogenic sprout endothelial tip cell increased branchiness , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte decreased pigmentation , abnormal
melanocyte colorless , abnormal
melanocyte unpigmented , abnormal
melanocyte intensity , abnormal
melanocyte absent , abnormal
melanocyte melanosome unpigmented , abnormal
melanocyte melanosome decreased pigmentation , abnormal
melanocyte melanosome circular , abnormal
melanocyte melanosome decreased size , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell apoptotic , abnormal
Show

 ZFA:0009223 green sensitive photoreceptor cell green sensitive photoreceptor cell hypertrophic , abnormal
green sensitive photoreceptor cell disorganized , abnormal
Show

 ZFA:0009224 red sensitive photoreceptor cell red sensitive photoreceptor cell hypertrophic , abnormal
red sensitive photoreceptor cell disorganized , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte accumulation ball , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
retinal cone cell photoreceptor outer segment decreased amount , abnormal
retinal cone cell irregular spatial pattern , abnormal
retinal cone cell photoreceptor outer segment absent , abnormal
retinal cone cell photoreceptor outer segment broken , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell photoreceptor inner segment increased size , abnormal
retinal rod cell decreased amount , abnormal
retinal rod cell photoreceptor outer segment increased size , abnormal
retinal rod cell photoreceptor outer segment decreased amount , abnormal
Show

 ZFA:0009280 Muller cell Muller cell morphology , abnormal
Muller cell decreased amount , abnormal
Muller cell apoptotic , abnormal
Muller cell apoptotic process increased occurrence , abnormal
Muller cell proliferative , abnormal
Muller cell cell proliferation increased occurrence , abnormal
Show

 ZFA:0009303 endothelial tip cell endothelial tip cell filopodium assembly increased occurrence , abnormal
Show

 ZFA:0009309 leukocyte leukocyte degeneration , abnormal
leukocyte mitochondrion swollen , abnormal
leukocyte endomembrane system broken , abnormal
leukocyte endomembrane system swollen , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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