ENSMUSG00000022243


Mus musculus

Features
Gene ID: ENSMUSG00000022243
  
Biological name :Slc45a2
  
Synonyms : P58355 / Slc45a2 / solute carrier family 45, member 2
  
Possible biological names infered from orthology : Q9UMX9
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 11000721
Gene end: 11029233
  
Corresponding Affymetrix probe sets: 10423098 (MoGene1.0st)   1437430_at (Mouse Genome 430 2.0 Array)   1451055_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112408
NCBI entrez gene - 22293     See in Manteia.
MGI - MGI:2153040
RefSeq - NM_053077
RefSeq Peptide - NP_444307
swissprot - P58355
swissprot - Q541S3
Ensembl - ENSMUSG00000022243
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc45a2ENSDARG00000002593Danio rerio
 SLC45A2ENSGALG00000003310Gallus gallus
 Q9UMX9ENSG00000164175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BIV7 / Slc45a1 / Proton-associated sugar transporter A / Q9Y2W3* / solute carrier family 45 member 1*ENSMUSG0000003983841
Q0P5V9 / Slc45a4 / Mus musculus solute carrier family 45, member 4 (Slc45a4), transcript variant 3, mRNA. / Q5BKX6* / solute carrier family 45 member 4*ENSMUSG0000007902036
Q8K0H7 / Slc45a3 / Solute carrier family 45 member 3 / Q96JT2*ENSMUSG0000002643524


Protein motifs (from Interpro)
Interpro ID Name
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0015770 sucrose transport IDA
 biological_processGO:0042438 melanin biosynthetic process IEA
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033162 melanosome membrane IEA
 molecular_functionGO:0008506 sucrose:proton symporter activity IDA


Pathways (from Reactome)
Pathway description
Melanin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Slc45a2uw-Btlr/Slc45a2uw-Btlr
Genetic Background: C57BL/6J-Slc45a2uw-Btlr

Allelic Composition: Slc45a2uw-2Btlr/Slc45a2uw-2Btlr
Genetic Background: C57BL/6J-Slc45a2uw-2Btlr

Allelic Composition: Slc45a2uw-3Btlr/Slc45a2uw-3Btlr
Genetic Background: C57BL/6J-Slc45a2uw-3Btlr

Allelic Composition: Slc45a2uw-4Btlr/Slc45a2uw-4Btlr
Genetic Background: C57BL/6J-Slc45a2uw-4Btlr

Allelic Composition: Slc45a2uw-6Btlr/Slc45a2uw-6Btlr
Genetic Background: C57BL/6J-Slc45a2uw-6Btlr

Allelic Composition: Slc45a2uw-5Btlr/Slc45a2uw-5Btlr
Genetic Background: C57BL/6J-Slc45a2uw-5Btlr

Allelic Composition: Slc45a2uw-7J/Slc45a2uw-7J
Genetic Background: C3H/HeJ-Slc45a2uw-7J/GrsrJ

Allelic Composition: Slc45a2uw-6J/Slc45a2uw-6J
Genetic Background: CAST/EiJ-Slc45a2uw-6J/GrsrJ

Allelic Composition: Slc45a2Ltct/Slc45a2Ltct
Genetic Background: involves: C3H/HeH

Allelic Composition: Slc45a2Ltct/Slc45a2+
Genetic Background: involves: C3H/HeH

Allelic Composition: Slc45a2uw-8Btlr/Slc45a2uw-8Btlr
Genetic Background: C57BL/6J-Slc45a2uw-8Btlr

Allelic Composition: Slc45a2uw-9Btlr/Slc45a2uw-9Btlr
Genetic Background: C57BL/6J-Slc45a2uw-9Btlr

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Slc45a2uw-d/Slc45a2uw-d
Genetic Background: TF/Le

Allelic Composition: Slc45a2Uw-dbr/Slc45a2Uw-dbr
Genetic Background: B10.PL-H2u/(73NS)Sn

Allelic Composition: Slc45a2Uw-dbr/Slc45a2+
Genetic Background: B10.PL-H2u/(73NS)Sn

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-d/Slc45a2uw-d
Genetic Background: TF/Le

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Slc45a2uw-4J/Slc45a2uw-4J
Genetic Background: C57BL/6J-Slc45a2uw-4J/Llp

Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Slc45a2uw-7Btlr/Slc45a2uw-7Btlr
Genetic Background: involves: C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hes7tm2Kag/Hes7+
Genetic Background: involves: ICR

Allelic Composition: Slc45a2uw-7Btlr/Slc45a2uw-7Btlr
Genetic Background: involves: C57BL/6J

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Slc45a2uw-Btlr/Slc45a2uw-Btlr
Genetic Background: C57BL/6J-Slc45a2uw-Btlr

Allelic Composition: Slc45a2uw-2Btlr/Slc45a2uw-2Btlr
Genetic Background: C57BL/6J-Slc45a2uw-2Btlr

Allelic Composition: Slc45a2uw-3Btlr/Slc45a2uw-3Btlr
Genetic Background: C57BL/6J-Slc45a2uw-3Btlr

Allelic Composition: Slc45a2uw-4Btlr/Slc45a2uw-4Btlr
Genetic Background: C57BL/6J-Slc45a2uw-4Btlr

Allelic Composition: Slc45a2uw-6Btlr/Slc45a2uw-6Btlr
Genetic Background: C57BL/6J-Slc45a2uw-6Btlr

Allelic Composition: Slc45a2uw-7J/Slc45a2uw-7J
Genetic Background: C3H/HeJ-Slc45a2uw-7J/GrsrJ

Allelic Composition: Slc45a2uw-6J/Slc45a2uw-6J
Genetic Background: CAST/EiJ-Slc45a2uw-6J/GrsrJ

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-4J/Slc45a2uw-4J
Genetic Background: C57BL/6J-Slc45a2uw-4J/Llp

Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Slc45a2uw-Btlr/Slc45a2uw-Btlr
Genetic Background: C57BL/6J-Slc45a2uw-Btlr

Allelic Composition: Slc45a2uw-2Btlr/Slc45a2uw-2Btlr
Genetic Background: C57BL/6J-Slc45a2uw-2Btlr

Allelic Composition: Slc45a2uw-3Btlr/Slc45a2uw-3Btlr
Genetic Background: C57BL/6J-Slc45a2uw-3Btlr

Allelic Composition: Slc45a2uw-4Btlr/Slc45a2uw-4Btlr
Genetic Background: C57BL/6J-Slc45a2uw-4Btlr

 MP:0008480 absent eye pigmentation "absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2Ltct/Slc45a2Ltct
Genetic Background: involves: C3H/HeH

 MP:0009928 abnormal pinna hair pigmentation "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased or increased in hair located behind the ears when compared to control animal pigmentation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2Ltct/Slc45a2+
Genetic Background: involves: C3H/HeH

 MP:0011627 decreased skin pigmentation "visually detectable dilution of pigment present in the skin" [MGI:csmith]
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Allelic Composition: Slc45a2uw-7J/Slc45a2uw-7J
Genetic Background: C3H/HeJ-Slc45a2uw-7J/GrsrJ

Allelic Composition: Slc45a2uw-6J/Slc45a2uw-6J
Genetic Background: CAST/EiJ-Slc45a2uw-6J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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