ENSDARG00000003189


Danio rerio

Features
Gene ID: ENSDARG00000003189
  
Biological name :psmd1
  
Synonyms : proteasome 26S subunit, non-ATPase 1 / psmd1
  
Possible biological names infered from orthology : Gm21972 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 / Q3TXS7 / Q99460
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 37631034
Gene end: 37716627
  
Corresponding Affymetrix probe sets: Dr.20879.1.A1_s_at (Zebrafish Array)   Dr.3103.1.S1_at (Zebrafish Array)   NM_201184_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000006823
Ensembl peptide - ENSDARP00000117676
Ensembl peptide - ENSDARP00000133612
Ensembl peptide - ENSDARP00000149973
NCBI entrez gene - 554967     See in Manteia.
RefSeq - XM_017353144
RefSeq - NM_201184
RefSeq Peptide - NP_957478
swissprot - F1QK93
swissprot - A0A0R4IJ38
swissprot - F1QY43
ZFIN ID - ZDB-GENE-040426-810
Ensembl - ENSDARG00000003189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD1ENSGALG00000007664Gallus gallus
 PSMD1ENSG00000173692Homo sapiens
 Gm21972ENSMUSG00000094638Mus musculus
 Psmd1ENSMUSG00000026229Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002015  Proteasome/cyclosome repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR016642  26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
 IPR035266  26S Proteasome non-ATPase regulatory subunit 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034515 proteasome storage granule IBA
 molecular_functionGO:0004175 endopeptidase activity IBA
 molecular_functionGO:0030234 enzyme regulator activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr