ENSMUSG00000026229


Mus musculus

Features
Gene ID: ENSMUSG00000026229
  
Biological name :Psmd1
  
Synonyms : proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 / Psmd1 / Q3TXS7
  
Possible biological names infered from orthology : proteasome 26S subunit, non-ATPase 1 / Q99460
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 86064387
Gene end: 86139151
  
Corresponding Affymetrix probe sets: 10348004 (MoGene1.0st)   1429291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122121
Ensembl peptide - ENSMUSP00000027432
NCBI entrez gene - 70247     See in Manteia.
MGI - MGI:1917497
RefSeq - NM_027357
RefSeq Peptide - NP_081633
swissprot - D6RGR5
swissprot - Q3TXS7
Ensembl - ENSMUSG00000026229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd1ENSDARG00000003189Danio rerio
 PSMD1ENSGALG00000007664Gallus gallus
 PSMD1ENSG00000173692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm21972 / PSMD1* / Q99460* / proteasome 26S subunit, non-ATPase 1*ENSMUSG0000009463810


Protein motifs (from Interpro)
Interpro ID Name
 IPR002015  Proteasome/cyclosome repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR016642  26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
 IPR035266  26S Proteasome non-ATPase regulatory subunit 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 cellular_componentGO:0034515 proteasome storage granule IBA
 molecular_functionGO:0004175 endopeptidase activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030234 enzyme regulator activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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