ENSDARG00000012247


Danio rerio

Features
Gene ID: ENSDARG00000012247
  
Biological name :def6a
  
Synonyms : def6a / differentially expressed in FDCP 6a homolog (mouse) / Q7SYB5
  
Possible biological names infered from orthology : DEF6 / DEF6, guanine nucleotide exchange factor / Q9H4E7
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 14185295
Gene end: 14209852
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000025016
NCBI entrez gene - 394015     See in Manteia.
RefSeq - NM_201040
RefSeq Peptide - NP_957334
swissprot - Q7SYB5
ZFIN ID - ZDB-GENE-040426-1246
Ensembl - ENSDARG00000012247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DEF6ENSGALG00000002615Gallus gallus
 DEF6ENSG00000023892Homo sapiens
 Def6ENSMUSG00000002257Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
def6c / differentially expressed in FDCP 6c homologENSDARG0000003471742
swap70b / switching B cell complex subunit SWAP70b / Q9UH65* / SWAP70* / Q6A028* / Switch-associated protein 70 * / switching B cell complex subunit SWAP70*ENSDARG0000005728642
swap70a / switching B cell complex subunit SWAP70a / Q9UH65* / SWAP70* / Q6A028* / Switch-associated protein 70 * / switching B cell complex subunit SWAP70*ENSDARG0000005181939
def6b / differentially expressed in FDCP 6b homolog (mouse) / DEF6* / Q9H4E7* / DEF6, guanine nucleotide exchange factor*ENSDARG0000004452438


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0005575 cellular_component ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000058 polster polster mislocalised posteriorly , abnormal
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 ZFA:0000060 prechordal plate prechordal plate morphology , abnormal
Show

 ZFA:0000077 tail bud tail bud truncated , abnormal
Show

 ZFA:0000092 axis axis decreased length , abnormal
Show

 ZFA:0000107 eye eye decreased distance eye , abnormal
eye increased distance eye , abnormal
Show

 ZFA:0000109 forebrain forebrain structure , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000135 notochord notochord decreased length , abnormal
notochord undulate , abnormal
notochord increased width , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm adaxial cell increased distance paraxial mesoderm adaxial cell, abnormal
Show

 ZFA:0000279 segmental plate segmental plate increased width , abnormal
segmental plate curved , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001114 head head anterior region flattened , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage shape , abnormal
Meckels cartilage decreased length , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage mislocalised posteriorly , abnormal
Show

 ZFA:0007029 hindbrain neural keel hindbrain neural keel increased width , abnormal
Show

 ZFA:0007045 midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural keel increased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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