ENSDARG00000013095


Danio rerio

Features
Gene ID: ENSDARG00000013095
  
Biological name :gclc
  
Synonyms : gclc / glutamate-cysteine ligase, catalytic subunit
  
Possible biological names infered from orthology : P48506 / P97494
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 2357637
Gene end: 2392664
  
Corresponding Affymetrix probe sets: Dr.7271.1.S1_at (Zebrafish Array)   NM_199277_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017790
NCBI entrez gene - 326857     See in Manteia.
RefSeq - NM_199277
RefSeq Peptide - NP_954971
swissprot - Q6NV35
ZFIN ID - ZDB-GENE-030131-5056
Ensembl - ENSDARG00000013095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GCLCENSGALG00000016313Gallus gallus
 GCLCENSG00000001084Homo sapiens
 GclcENSMUSG00000032350Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004308  Glutamate-cysteine ligase catalytic subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006534 cysteine metabolic process ISS
 biological_processGO:0006536 glutamate metabolic process ISS
 biological_processGO:0006750 glutathione biosynthetic process IBA
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0009408 response to heat ISS
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0045454 cell redox homeostasis ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0050880 regulation of blood vessel size ISS
 cellular_componentGO:0017109 glutamate-cysteine ligase complex IBA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004357 glutamate-cysteine ligase activity IBA
 molecular_functionGO:0016595 glutamate binding ISS
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0043531 ADP binding ISS
 molecular_functionGO:0050662 coenzyme binding ISS


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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