ENSMUSG00000032350


Mus musculus

Features
Gene ID: ENSMUSG00000032350
  
Biological name :Gclc
  
Synonyms : Gclc / Glutamate--cysteine ligase catalytic subunit / P97494
  
Possible biological names infered from orthology : P48506
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 77754535
Gene end: 77794485
  
Corresponding Affymetrix probe sets: 10587266 (MoGene1.0st)   1424296_at (Mouse Genome 430 2.0 Array)   1455959_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034905
NCBI entrez gene - 14629     See in Manteia.
MGI - MGI:104990
RefSeq - XM_006510812
RefSeq - NM_010295
RefSeq Peptide - NP_034425
swissprot - P97494
swissprot - Q3TEF1
Ensembl - ENSMUSG00000032350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gclcENSDARG00000013095Danio rerio
 GCLCENSGALG00000016313Gallus gallus
 GCLCENSG00000001084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004308  Glutamate-cysteine ligase catalytic subunit
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006534 cysteine metabolic process IEA
 biological_processGO:0006536 glutamate metabolic process IEA
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0006750 glutathione biosynthetic process ISS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IGI
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009410 response to xenobiotic stimulus IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019852 L-ascorbic acid metabolic process IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046685 response to arsenic-containing substance IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0051900 regulation of mitochondrial depolarization IGI
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0097069 cellular response to thyroxine stimulus IEA
 biological_processGO:2000490 negative regulation of hepatic stellate cell activation IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0017109 glutamate-cysteine ligase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004357 glutamate-cysteine ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050662 coenzyme binding IEA


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gclmtm1Tdal/Gclmtm1Tdal
Genetic Background: B6.129-Gclmtm1Tdal

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

Allelic Composition: Gclctm1c(EUCOMM)Wtsi/Gclc+,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gclmtm1Tdal/Gclmtm1Tdal
Genetic Background: B6.129-Gclmtm1Tdal

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: FVB

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Gclctm1Tdal/Gclctm1Tdal,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Glo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028124 Gclm / O09172 / Glutamate--cysteine ligase regulatory subunit / P48507* / glutamate-cysteine ligase modifier subunit*  / complex






 

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