ENSMUSG00000028124


Mus musculus

Features
Gene ID: ENSMUSG00000028124
  
Biological name :Gclm
  
Synonyms : Gclm / Glutamate--cysteine ligase regulatory subunit / O09172
  
Possible biological names infered from orthology : glutamate-cysteine ligase modifier subunit / P48507
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 122245557
Gene end: 122270732
  
Corresponding Affymetrix probe sets: 10374175 (MoGene1.0st)   10441396 (MoGene1.0st)   10482507 (MoGene1.0st)   10495763 (MoGene1.0st)   10545337 (MoGene1.0st)   10567574 (MoGene1.0st)   10588024 (MoGene1.0st)   1417451_a_at (Mouse Genome 430 2.0 Array)   1418627_at (Mouse Genome 430 2.0 Array)   1439050_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136987
Ensembl peptide - ENSMUSP00000123683
Ensembl peptide - ENSMUSP00000029769
Ensembl peptide - ENSMUSP00000134906
Ensembl peptide - ENSMUSP00000142381
NCBI entrez gene - 14630     See in Manteia.
MGI - MGI:104995
RefSeq - NM_008129
RefSeq Peptide - NP_032155
swissprot - Q4FJZ6
swissprot - A0A0G2JDI4
swissprot - F6VNW5
swissprot - H3BJA3
swissprot - O09172
Ensembl - ENSMUSG00000028124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gclmENSDARG00000018953Danio rerio
 GCLMENSG00000023909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR023210  NADP-dependent oxidoreductase domain
 IPR032963  Glutamate--cysteine ligase regulatory subunit
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006534 cysteine metabolic process IMP
 biological_processGO:0006536 glutamate metabolic process ISO
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0006750 glutathione biosynthetic process ISS
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IGI
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0035229 positive regulation of glutamate-cysteine ligase activity IDA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035733 hepatic stellate cell activation IEA
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0050880 regulation of blood vessel size ISO
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0051900 regulation of mitochondrial depolarization IGI
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0097069 cellular response to thyroxine stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0017109 glutamate-cysteine ligase complex IDA
 molecular_functionGO:0004357 glutamate-cysteine ligase activity ISO
 molecular_functionGO:0030234 enzyme regulator activity IBA
 molecular_functionGO:0035226 glutamate-cysteine ligase catalytic subunit binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gclmtm1Tdal/Gclmtm1Tdal
Genetic Background: B6.129-Gclmtm1Tdal

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gclmtm1Tdal/Gclmtm1Tdal
Genetic Background: B6.129-Gclmtm1Tdal

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: B6.129-Gclmtm1Tjka

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: B6.129-Gclmtm1Tjka

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: B6.129-Gclmtm1Tjka

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: B6.129-Gclmtm1Tjka

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gclmtm1Tjka/Gclmtm1Tjka
Genetic Background: B6.129-Gclmtm1Tjka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032350 Gclc / P97494 / Glutamate--cysteine ligase catalytic subunit / P48506*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr