ENSG00000023909


Homo sapiens

Features
Gene ID: ENSG00000023909
  
Biological name :GCLM
  
Synonyms : GCLM / glutamate-cysteine ligase modifier subunit / P48507
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p22.1
Gene start: 93885205
Gene end: 93909456
  
Corresponding Affymetrix probe sets: 203925_at (Human Genome U133 Plus 2.0 Array)   234986_at (Human Genome U133 Plus 2.0 Array)   236140_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359258
Ensembl peptide - ENSP00000484507
NCBI entrez gene - 2730     See in Manteia.
OMIM - 601176
RefSeq - XM_017001057
RefSeq - NM_001308253
RefSeq - NM_002061
RefSeq - XM_011541261
RefSeq - XM_017001056
RefSeq Peptide - NP_001295182
RefSeq Peptide - NP_002052
swissprot - P48507
Ensembl - ENSG00000023909
  
Related genetic diseases (OMIM): 608446 - {Myocardial infarction, susceptibility to}, 608446
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gclmENSDARG00000018953Danio rerio
 GclmENSMUSG00000028124Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR023210  NADP-dependent oxidoreductase domain
 IPR032963  Glutamate--cysteine ligase regulatory subunit
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006534 cysteine metabolic process IEA
 biological_processGO:0006536 glutamate metabolic process IDA
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0006750 glutathione biosynthetic process IMP
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0035229 positive regulation of glutamate-cysteine ligase activity IBA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035733 hepatic stellate cell activation IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0050880 regulation of blood vessel size IMP
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0051900 regulation of mitochondrial depolarization IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0097069 cellular response to thyroxine stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0017109 glutamate-cysteine ligase complex IBA
 molecular_functionGO:0004357 glutamate-cysteine ligase activity IMP
 molecular_functionGO:0030234 enzyme regulator activity IBA
 molecular_functionGO:0035226 glutamate-cysteine ligase catalytic subunit binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000001084 GCLC / P48506 / glutamate-cysteine ligase catalytic subunit  / complex






 

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