ENSDARG00000017740


Danio rerio

Features
Gene ID: ENSDARG00000017740
  
Biological name :sec63
  
Synonyms : sec63 / SEC63 homolog, protein translocation regulator
  
Possible biological names infered from orthology : Mus musculus SEC63-like (S. cerevisiae) (Sec63), transcript variant 2, mRNA. / Q8VHE0 / Q9UGP8
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 32501748
Gene end: 32521973
  
Corresponding Affymetrix probe sets: Dr.26145.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000006629
Ensembl peptide - ENSDARP00000127113
swissprot - F1QGI2
ZFIN ID - ZDB-GENE-040718-328
Ensembl - ENSDARG00000017740
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEC63ENSGALG00000015308Gallus gallus
 SEC63ENSG00000025796Homo sapiens
 Sec63ENSMUSG00000019802Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001623  DnaJ domain
 IPR004179  Sec63 domain
 IPR014756  Immunoglobulin E-set
 IPR027137  Translocation protein Sec63


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0031204 posttranslational protein targeting to membrane, translocation IEA
 biological_processGO:0042552 myelination IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord axon morphology , abnormal
spinal cord node of Ranvier morphology , abnormal
spinal cord node of Ranvier decreased amount , abnormal
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 ZFA:0000123 liver liver fatty , abnormal
liver mitochondrion decreased size , abnormal
liver endoplasmic reticulum broken , abnormal
liver endoplasmic reticulum swollen , abnormal
liver endoplasmic reticulum lumen morphology , abnormal
liver mitochondrial crista increased width , abnormal
liver bile canaliculus disorganized , abnormal
liver cystic , abnormal
liver endoplasmic reticulum disoriented , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve node of Ranvier morphology , abnormal
posterior lateral line nerve node of Ranvier decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism curved lateral , abnormal
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 ZFA:0009076 oligodendrocyte oligodendrocyte endoplasmic reticulum swollen , abnormal
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 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell endoplasmic reticulum swollen , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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