ENSMUSG00000019802


Mus musculus

Features
Gene ID: ENSMUSG00000019802
  
Biological name :Sec63
  
Synonyms : Mus musculus SEC63-like (S. cerevisiae) (Sec63), transcript variant 2, mRNA. / Q8VHE0 / Sec63
  
Possible biological names infered from orthology : Q9UGP8 / SEC63 homolog, protein translocation regulator
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B2
Gene start: 42761496
Gene end: 42832514
  
Corresponding Affymetrix probe sets: 10362837 (MoGene1.0st)   1419819_s_at (Mouse Genome 430 2.0 Array)   1424924_at (Mouse Genome 430 2.0 Array)   1424925_at (Mouse Genome 430 2.0 Array)   1424926_at (Mouse Genome 430 2.0 Array)   1452854_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019937
NCBI entrez gene - 140740     See in Manteia.
MGI - MGI:2155302
RefSeq - NM_001359285
RefSeq - NM_001359286
RefSeq - NM_153055
RefSeq - XM_017313801
RefSeq - NM_001359283
RefSeq - NM_001359284
RefSeq - XM_011243116
RefSeq - XM_017313800
RefSeq Peptide - NP_001346215
RefSeq Peptide - NP_694695
RefSeq Peptide - NP_001346212
RefSeq Peptide - NP_001346213
RefSeq Peptide - NP_001346214
swissprot - Q8VHE0
Ensembl - ENSMUSG00000019802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec63ENSDARG00000017740Danio rerio
 SEC63ENSGALG00000015308Gallus gallus
 SEC63ENSG00000025796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR004179  Sec63 domain
 IPR014756  Immunoglobulin E-set
 IPR027137  Translocation protein Sec63
 IPR035892  C2 domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA
 biological_processGO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane IEA
 biological_processGO:0006807 nitrogen compound metabolic process IGI
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031204 posttranslational protein targeting to membrane, translocation IEA
 biological_processGO:0072001 renal system development IGI
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003327 liver cysts "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Sec63tm1Som/Sec63tm1Som,Tg(Pdk1)248Som/0,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

Allelic Composition: Pkd2tm2Som/Pkd2+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

Allelic Composition: Pkd2tm2Som/Pkd2+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011344 abnormal loop of Henle ascending limb thick segment morphology "any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Sec63tm1Som/Sec63tm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027706 Sec62 / Q8BU14 / Translocation protein SEC62 / Q99442* / SEC62 homolog, preprotein translocation factor*  / complex
 ENSMUSG00000025816 Q9JLR1 / Sec61a2 / Sec61, alpha subunit 2 (S. cerevisiae) / Q9H9S3* / Sec61 translocon alpha 2 subunit*  / complex
 ENSMUSG00000030082 P61620 / Sec61a1 / Protein transport protein Sec61 subunit alpha isoform 1 / P61619* / Sec61 translocon alpha 1 subunit*  / complex
 ENSMUSG00000053317 Q9CQS8 / Sec61b / Protein transport protein Sec61 subunit beta / P60468* / Sec61 translocon beta subunit*  / complex
 ENSMUSG00000052456 Asna1 / O54984 / ATPase Asna1 / O43681* / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)*  / reaction
 ENSMUSG00000078974 P60060 / Sec61g / Protein transport protein Sec61 subunit gamma / P60059* / Sec61 translocon gamma subunit*  / complex






 

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