ENSMUSG00000030082


Mus musculus

Features
Gene ID: ENSMUSG00000030082
  
Biological name :Sec61a1
  
Synonyms : P61620 / Protein transport protein Sec61 subunit alpha isoform 1 / Sec61a1
  
Possible biological names infered from orthology : P61619 / Sec61 translocon alpha 1 subunit
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 88503579
Gene end: 88518905
  
Corresponding Affymetrix probe sets: 10546113 (MoGene1.0st)   1416189_a_at (Mouse Genome 430 2.0 Array)   1416190_a_at (Mouse Genome 430 2.0 Array)   1416191_at (Mouse Genome 430 2.0 Array)   1434986_a_at (Mouse Genome 430 2.0 Array)   1448242_at (Mouse Genome 430 2.0 Array)   1455987_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032168
NCBI entrez gene - 53421     See in Manteia.
MGI - MGI:1858417
RefSeq - NM_016906
RefSeq Peptide - NP_058602
swissprot - P61620
Ensembl - ENSMUSG00000030082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90ZM2ENSDARG00000021669Danio rerio
 sec61a1lENSDARG00000005675Danio rerio
 SEC61A1ENSGALG00000005966Gallus gallus
 P61619ENSG00000058262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JLR1 / Sec61a2 / Sec61, alpha subunit 2 (S. cerevisiae) / Q9H9S3* / Sec61 translocon alpha 2 subunit*ENSMUSG0000002581693


Protein motifs (from Interpro)
Interpro ID Name
 IPR002208  SecY/SEC61-alpha family
 IPR019561  Translocon Sec61/SecY, plug domain
 IPR023201  SecY domain superfamily
 IPR030659  SecY conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006613 cotranslational protein targeting to membrane IEA
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA
 biological_processGO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane IEA
 biological_processGO:0007029 endoplasmic reticulum organization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0039019 pronephric nephron development IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 molecular_functionGO:0022857 transmembrane transporter activity EXP
 molecular_functionGO:0043022 ribosome binding IDA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0003046 liver cirrhosis "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0005218 abnormal pancreatic delta cell morphology "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0009180 increased pancreatic delta cell number "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0014117 increased pancreatic beta cell apoptosis "increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek
Genetic Background: C57BL/6J-Sec61a1m1Gek

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025816 Q9JLR1 / Sec61a2 / Sec61, alpha subunit 2 (S. cerevisiae) / Q9H9S3* / Sec61 translocon alpha 2 subunit*  / complex
 ENSMUSG00000027706 Sec62 / Q8BU14 / Translocation protein SEC62 / Q99442* / SEC62 homolog, preprotein translocation factor*  / complex
 ENSMUSG00000019802 Sec63 / Q8VHE0 / Mus musculus SEC63-like (S. cerevisiae) (Sec63), transcript variant 2, mRNA. / Q9UGP8* / SEC63 homolog, protein translocation regulator*  / complex
 ENSMUSG00000053317 Q9CQS8 / Sec61b / Protein transport protein Sec61 subunit beta / P60468* / Sec61 translocon beta subunit*  / complex
 ENSMUSG00000052456 Asna1 / O54984 / ATPase Asna1 / O43681* / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)*  / reaction
 ENSMUSG00000078974 P60060 / Sec61g / Protein transport protein Sec61 subunit gamma / P60059* / Sec61 translocon gamma subunit*  / complex






 

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