ENSDARG00000021669


Danio rerio

Features
Gene ID: ENSDARG00000021669
  
Biological name :sec61a1
  
Synonyms : Q90ZM2 / sec61a1 / Sec61 translocon alpha 1 subunit
  
Possible biological names infered from orthology : P61619 / P61620 / Protein transport protein Sec61 subunit alpha isoform 1
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 40065201
Gene end: 40071899
  
Corresponding Affymetrix probe sets: Dr.24814.1.S1_at (Zebrafish Array)   NM_153659_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000033318
NCBI entrez gene - 192298     See in Manteia.
RefSeq - NM_153659
RefSeq Peptide - NP_705945
swissprot - Q90ZM2
ZFIN ID - ZDB-GENE-020418-2
Ensembl - ENSDARG00000021669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEC61A1ENSGALG00000005966Gallus gallus
 P61619ENSG00000058262Homo sapiens
 P61620ENSMUSG00000030082Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sec61a1l / Sec61 translocon alpha 1 subunit, like / P61620* / P61619* / SEC61A1* / Sec61 translocon alpha 1 subunit* / Protein transport protein Sec61 subunit alpha isoform 1 *ENSDARG0000000567598


Protein motifs (from Interpro)
Interpro ID Name
 IPR002208  SecY/SEC61-alpha family
 IPR019561  Translocon Sec61/SecY, plug domain
 IPR023201  SecY domain superfamily
 IPR030659  SecY conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0039019 pronephric nephron development IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
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 ZFA:0000100 cerebellum cerebellum has extra parts of type neuron , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000123 liver liver quality , abnormal
liver hypoplastic , abnormal
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 ZFA:0000161 third ventricle third ventricle epithelium morphology , abnormal
third ventricle columnar/cuboidal epithelial cell circular , abnormal
third ventricle columnar/cuboidal epithelial cell cellular adhesivity third ventricle columnar/cuboidal epithelial cell, abnormal
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 ZFA:0000197 dorsal habenular nucleus dorsal habenular nucleus morphology , abnormal
dorsal habenular nucleus lateral region has extra parts of type neuron , abnormal
dorsal habenular nucleus right side has extra parts of type neuron , abnormal
dorsal habenular nucleus medial region has fewer parts of type neuron , abnormal
dorsal habenular nucleus neuron spatial pattern , abnormal
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 ZFA:0000213 habenula habenula left side has extra parts of type neuron , abnormal
habenula right side has extra parts of type neuron , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000672 hyomandibula hyomandibula decreased size , abnormal
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 ZFA:0001094 whole organism whole organism bent , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism anterior-posterior axis curved dorsal , abnormal
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 ZFA:0001114 head head decreased volume , abnormal
head decreased size , abnormal
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 ZFA:0001115 trunk trunk curved dorsal , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton extracellular matrix sparse , abnormal
mandibular arch skeleton chondrocyte cellular quality , abnormal
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 ZFA:0001501 cartilage element cartilage element morphology , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 decreased size , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 decreased size , abnormal
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 ZFA:0001617 otolith otolith quality , abnormal
otolith decreased size , abnormal
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 ZFA:0009038 columnar/cuboidal epithelial cell columnar/cuboidal epithelial cell cell-cell junction decreased amount , abnormal
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 ZFA:0009084 chondrocyte chondrocyte endoplasmic reticulum decreased volume , abnormal
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 ZFA:0009306 neuroepithelial cell neuroepithelial cell filamentous actin decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018190 asna1 / Q6IQE5 / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) / O43681* / O54984* / ATPase Asna1 *  / reaction
 ENSDARG00000018637 sec61g / Sec61 translocon gamma subunit / P60059* / P60060* / Protein transport protein Sec61 subunit gamma *  / complex
 ENSDARG00000076568 sec61b / Sec61 translocon beta subunit / P60468* / Q9CQS8* / Gm10320* / Protein transport protein Sec61 subunit beta *  / complex






 

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