ENSDARG00000021124


Danio rerio

Features
Gene ID: ENSDARG00000021124
  
Biological name :cfl1
  
Synonyms : cfl1 / cofilin 1
  
Possible biological names infered from orthology : P18760 / P23528
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 30795559
Gene end: 30801555
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000023177
NCBI entrez gene - 321496     See in Manteia.
RefSeq - NM_213641
RefSeq Peptide - NP_998806
swissprot - Q6TH32
ZFIN ID - ZDB-GENE-030131-215
Ensembl - ENSDARG00000021124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFL1ENSG00000172757Homo sapiens
 Cfl1ENSMUSG00000056201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cfl2 / cofilin 2 (muscle) / P45591* / Q9Y281* / cofilin 2*ENSDARG0000001410678
cfl1l / cofilin 1 (non-muscle), like / DSTN* / P60981* / Q9R0P5* / Destrin * / destrin, actin depolymerizing factor*ENSDARG0000001297232


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR017904  ADF/Cofilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0030030 cell projection organization IMP
 biological_processGO:0030042 actin filament depolymerization IEA
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 biological_processGO:0060271 cilium assembly IGI
 biological_processGO:0061371 determination of heart left/right asymmetry IGI
 biological_processGO:0070586 cell-cell adhesion involved in gastrulation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium increased length , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate cell projection decreased amount , abnormal
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 ZFA:0000076 swim bladder swim bladder absent , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
yolk edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000117 hypoblast hypoblast cell projection decreased amount , abnormal
Show

 ZFA:0000151 pronephros pronephros decreased functionality , abnormal
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 ZFA:0000360 heart tube heart tube mislocalised medially , abnormal
heart tube displaced to whole organism right side, abnormal
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 ZFA:0000711 DEL DEL detached from EVL , abnormal
DEL circular , abnormal
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 ZFA:0001094 whole organism whole organism increased curvature , abnormal
whole organism axis decreased length , abnormal
whole organism axis increased width , abnormal
whole organism curved , abnormal
Show

 ZFA:0001114 head head quality , abnormal
Show

 ZFA:0001176 blastoderm blastoderm filamentous actin increased amount , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
Show

 ZFA:0001674 mesonephric podocyte mesonephric podocyte structure , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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