ENSG00000172757


Homo sapiens

Features
Gene ID: ENSG00000172757
  
Biological name :CFL1
  
Synonyms : CFL1 / cofilin 1 / P23528
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 65823022
Gene end: 65862026
  
Corresponding Affymetrix probe sets: 1555730_a_at (Human Genome U133 Plus 2.0 Array)   200021_at (Human Genome U133 Plus 2.0 Array)   230870_at (Human Genome U133 Plus 2.0 Array)   236792_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432226
Ensembl peptide - ENSP00000436899
Ensembl peptide - ENSP00000436431
Ensembl peptide - ENSP00000433910
Ensembl peptide - ENSP00000433308
Ensembl peptide - ENSP00000433131
Ensembl peptide - ENSP00000432660
Ensembl peptide - ENSP00000309629
Ensembl peptide - ENSP00000431696
Ensembl peptide - ENSP00000432153
Ensembl peptide - ENSP00000432155
NCBI entrez gene - 1072     See in Manteia.
OMIM - 601442
RefSeq - NM_005507
RefSeq Peptide - NP_005498
swissprot - E9PLJ3
swissprot - E9PK25
swissprot - G3V1A4
swissprot - P23528
swissprot - E9PS23
swissprot - V9HWI5
swissprot - E9PQB7
swissprot - E9PP50
Ensembl - ENSG00000172757
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfl1ENSDARG00000021124Danio rerio
 Cfl1ENSMUSG00000056201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CFL2 / Q9Y281 / cofilin 2ENSG0000016541077
DSTN / P60981 / destrin, actin depolymerizing factorENSG0000012586842


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR017904  ADF/Cofilin
 IPR027234  Cofilin 1
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001842 neural fold formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0022604 regulation of cell morphogenesis IMP
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030042 actin filament depolymerization NAS
 biological_processGO:0030043 actin filament fragmentation IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0044794 positive regulation by host of viral process IMP
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
Sema3A PAK dependent Axon repulsion
RHO GTPases Activate ROCKs
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / reaction / complex






 

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