ENSG00000125868


Homo sapiens

Features
Gene ID: ENSG00000125868
  
Biological name :DSTN
  
Synonyms : destrin, actin depolymerizing factor / DSTN / P60981
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p12.1
Gene start: 17569863
Gene end: 17609919
  
Corresponding Affymetrix probe sets: 201021_s_at (Human Genome U133 Plus 2.0 Array)   201022_s_at (Human Genome U133 Plus 2.0 Array)   230933_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246069
Ensembl peptide - ENSP00000434355
Ensembl peptide - ENSP00000476975
NCBI entrez gene - 11034     See in Manteia.
OMIM - 609114
RefSeq - XM_011529144
RefSeq - NM_001011546
RefSeq - NM_006870
RefSeq - XM_011529142
RefSeq - XM_011529143
RefSeq Peptide - NP_001011546
RefSeq Peptide - NP_006861
swissprot - P60981
swissprot - V9HWA6
swissprot - F6RFD5
Ensembl - ENSG00000125868
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfl1lENSDARG00000012972Danio rerio
 DSTNENSGALG00000008667Gallus gallus
 DstnENSMUSG00000015932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CFL1 / P23528 / cofilin 1ENSG0000017275742
CFL2 / Q9Y281 / cofilin 2ENSG0000016541039


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR017904  ADF/Cofilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029924  Destrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008154 actin polymerization or depolymerization TAS
 biological_processGO:0030042 actin filament depolymerization IEA
 biological_processGO:0030043 actin filament fragmentation IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0051014 actin filament severing IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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