ENSMUSG00000015932


Mus musculus

Features
Gene ID: ENSMUSG00000015932
  
Biological name :Dstn
  
Synonyms : Destrin / Dstn / Q9R0P5
  
Possible biological names infered from orthology : destrin, actin depolymerizing factor / P60981
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G1
Gene start: 143915320
Gene end: 143943324
  
Corresponding Affymetrix probe sets: 10476648 (MoGene1.0st)   1417124_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099461
NCBI entrez gene - 56431     See in Manteia.
MGI - MGI:1929270
RefSeq - NM_019771
RefSeq Peptide - NP_062745
swissprot - Q4FK36
swissprot - Q9R0P5
Ensembl - ENSMUSG00000015932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfl1lENSDARG00000012972Danio rerio
 DSTNENSGALG00000008667Gallus gallus
 DSTNENSG00000125868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cfl1 / P18760 / Cofilin-1 / P23528*ENSMUSG0000005620142
Cfl2 / P45591 / Cofilin-2 / Q9Y281*ENSMUSG0000006292939


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR017904  ADF/Cofilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029924  Destrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030042 actin filament depolymerization IDA
 biological_processGO:0030043 actin filament fragmentation IDA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IMP
 biological_processGO:0051014 actin filament severing IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dstncorn1/Dstncorn1
Genetic Background: involves: A/WySn * brachy stock * C57BL/6JSmn

Allelic Composition: Dstncorn1/Dstncorn1,Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock

Allelic Composition: Dstntm1.1Wit/Dstntm1.1Wit
Genetic Background: involves: BALB/cJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Cfl1c5/Cfl1c5,Dstncorn1/Dstn+
Genetic Background: involves: A/WySn * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dstntm1.1Wit/Dstntm1.1Wit
Genetic Background: involves: BALB/cJ

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfl1c5/Cfl1c5,Dstncorn1/Dstn+
Genetic Background: involves: A/WySn * C57BL/6J

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dstncorn1/Dstncorn1
Genetic Background: involves: A/WySn * brachy stock * C57BL/6JSmn

Allelic Composition: Dstncorn1/Dstncorn1,Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

Allelic Composition: Dstncorn1/Dstncorn1-2J
Genetic Background: involves: A/WySn * brachy stock * C57BL/6JSmn

Allelic Composition: Dstncorn1/Dstncorn1
Genetic Background: involves: A/WySn * brachy stock * C57BL/6JSmn

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfl1c5/Cfl1c5,Dstncorn1/Dstn+
Genetic Background: involves: A/WySn * C57BL/6J

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Fancltm1Ceb/Fancltm1Ceb
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr