ENSMUSG00000062929


Mus musculus

Features
Gene ID: ENSMUSG00000062929
  
Biological name :Cfl2
  
Synonyms : Cfl2 / Cofilin-2 / P45591
  
Possible biological names infered from orthology : Q9Y281
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 54858809
Gene end: 54862877
  
Corresponding Affymetrix probe sets: 10400350 (MoGene1.0st)   1418066_at (Mouse Genome 430 2.0 Array)   1418067_at (Mouse Genome 430 2.0 Array)   1431432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077262
Ensembl peptide - ENSMUSP00000152320
NCBI entrez gene - 12632     See in Manteia.
MGI - MGI:101763
RefSeq - XM_006515452
RefSeq - NM_007688
RefSeq Peptide - NP_031714
swissprot - P45591
swissprot - Q3UHW9
swissprot - A0A1Y7VJ71
Ensembl - ENSMUSG00000062929
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfl2ENSDARG00000014106Danio rerio
 CFL2ENSGALG00000010027Gallus gallus
 CFL2ENSG00000165410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cfl1 / P18760 / Cofilin-1 / P23528*ENSMUSG0000005620178
Dstn / Q9R0P5 / Destrin / P60981* / destrin, actin depolymerizing factor*ENSMUSG0000001593239


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR017904  ADF/Cofilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0030042 actin filament depolymerization ISO
 biological_processGO:0030043 actin filament fragmentation IDA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031674 I band IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(Mef2c-cre)1Blk/0
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(Mef2c-cre)1Blk/0
Genetic Background: involves: C57BL/6NTac

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Cfl2tm1Itl/Cfl2tm1Itl,Tg(Mef2c-cre)1Blk/0
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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