ENSDARG00000037865


Danio rerio

Features
Gene ID: ENSDARG00000037865
  
Biological name :cln3
  
Synonyms : ceroid-lipofuscinosis, neuronal 3 / cln3
  
Possible biological names infered from orthology : AC138894.1 / Battenin / CLN3, battenin / Q13286 / Q61124
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 39579393
Gene end: 39599339
  
Corresponding Affymetrix probe sets: Dr.3167.1.A1_at (Zebrafish Array)   NM_001007306_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055169
NCBI entrez gene - 492340     See in Manteia.
RefSeq - NM_001007306
RefSeq Peptide - NP_001007307
swissprot - Q5U392
ZFIN ID - ZDB-GENE-041114-174
Ensembl - ENSDARG00000037865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC138894.1ENSG00000261832Homo sapiens
 CLN3ENSG00000188603Homo sapiens
 Cln3ENSMUSG00000030720Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003492  Batten"s disease protein Cln3
 IPR018460  Batten"s disease protein Cln3, subgroup
 IPR020846  Major facilitator superfamily domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007034 vacuolar transport IBA
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0015809 arginine transport IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0051453 regulation of intracellular pH IBA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain lysosome hypertrophic , abnormal
brain axon disorganized , abnormal
brain axon aggregated , abnormal
brain cell apoptotic , abnormal
brain astrocyte increased amount , abnormal
brain decreased size , abnormal
brain neuron decreased amount , abnormal
Show

 ZFA:0000029 hindbrain hindbrain size , abnormal
Show

 ZFA:0000054 pericardium pericardium increased size , abnormal
pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord astrocyte increased amount , abnormal
Show

 ZFA:0000084 yolk yolk increased size , abnormal
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 ZFA:0000107 eye eye mitochondrion morphology , abnormal
Show

 ZFA:0000109 forebrain forebrain apoptotic body increased amount , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000128 midbrain midbrain decreased size , abnormal
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 ZFA:0000152 retina retina decreased size , abnormal
retina cell proliferation disrupted , abnormal
retina cell apoptotic , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased width , abnormal
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 ZFA:0000445 optic tectum optic tectum axon absent , abnormal
optic tectum regulation of neuronal action potential disrupted , abnormal
Show

 ZFA:0001094 whole organism whole organism thigmotaxis disrupted , abnormal
whole organism lysosome increased size , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0009248 neuron neuron morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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