ENSDARG00000042112


Danio rerio

Features
Gene ID: ENSDARG00000042112
  
Biological name :dio1
  
Synonyms : dio1 / iodothyronine deiodinase 1
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 18039570
Gene end: 18042089
  
Corresponding Affymetrix probe sets: Dr.24960.1.S1_at (Zebrafish Array)   NM_001007283_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000121555
NCBI entrez gene - 799937     See in Manteia.
RefSeq - NM_001324404
RefSeq - NM_001007283
RefSeq Peptide - NP_001007284
RefSeq Peptide - NP_001311333
swissprot - F1R7E6
ZFIN ID - ZDB-GENE-030328-41
Ensembl - ENSDARG00000042112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DIO1ENSGALG00000010736Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dio2 / iodothyronine deiodinase 2 / Q92813* / Q9Z1Y9* / Type II iodothyronine deiodinase *ENSDARG0000009485729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR012336  Thioredoxin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061074 regulation of neural retina development IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer increased thickness , abnormal
retinal ganglion cell layer retinal ganglion cell sparse , abnormal
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 ZFA:0000107 eye eye decreased area , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer has fewer parts of type retinal cone cell , abnormal
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer UV sensitive photoreceptor cell, abnormal
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer blue sensitive photoreceptor cell, abnormal
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer green sensitive photoreceptor cell, abnormal
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer red sensitive photoreceptor cell, abnormal
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 ZFA:0000217 inner ear inner ear aplastic , abnormal
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 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism curved ventral , abnormal
whole organism decreased pigmentation , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head orientation trunk , abnormal
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 ZFA:0001117 post-vent region post-vent region truncated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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