ENSDARG00000094857


Danio rerio

Features
Gene ID: ENSDARG00000094857
  
Biological name :dio2
  
Synonyms : dio2 / iodothyronine deiodinase 2
  
Possible biological names infered from orthology : Q92813 / Q9Z1Y9 / Type II iodothyronine deiodinase
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 16873417
Gene end: 16876752
  
Corresponding Affymetrix probe sets: Dr.12949.1.S1_at (Zebrafish Array)   NM_212789_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000120358
NCBI entrez gene - 352937     See in Manteia.
RefSeq - NM_212789
RefSeq Peptide - NP_997954
swissprot - E9QGM3
ZFIN ID - ZDB-GENE-030327-4
Ensembl - ENSDARG00000094857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DIO2ENSGALG00000026005Gallus gallus
 DIO2ENSG00000211448Homo sapiens
 Dio2ENSMUSG00000007682Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dio1 / iodothyronine deiodinase 1ENSDARG0000004211229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR012336  Thioredoxin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000003 reproduction IMP
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061074 regulation of neural retina development IGI
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased amount , abnormal
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 ZFA:0000076 swim bladder swim bladder non-functional , abnormal
swim bladder decreased functionality , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart increased amount , abnormal
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 ZFA:0000118 hypophysis hypophysis increased amount , abnormal
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 ZFA:0000123 liver liver absent , abnormal
liver increased amount , abnormal
liver decreased amount , abnormal
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 ZFA:0000217 inner ear inner ear hypoplastic , abnormal
inner ear decreased size , abnormal
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 ZFA:0000622 barbel barbel absent , abnormal
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 ZFA:0001094 whole organism whole organism hypoplastic , abnormal
whole organism decreased pigmentation , abnormal
whole organism decreased length , abnormal
whole organism decreased mobility , abnormal
whole organism decreased female fertility , abnormal
whole organism decreased male fertility , abnormal
whole organism dead , abnormal
whole organism decreased size , abnormal
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 ZFA:0001114 head head orientation trunk , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle increased amount , abnormal
skeletal muscle decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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